Shock is a systemic form of acute circulatory failure leading to cellular dysoxia and death.
Such a state of aerobic metabolism failure also underlies neuronal cell death in severe …

Severe traumatic brain injury (TBI) is a heterogeneous pathophysiologic entity where
multiple interacting mechanisms are operating. This viewpoint offers an emerging, clinically …

Objective: To determine the effect of normobaric hyperoxia on cerebral metabolism in
patients with severe traumatic brain injury. Design: Prospective clinical investigation. Setting …

Background: Ischemic and hypoxic secondary brain insults are common and detrimental in
traumatic brain injury (TBI). Treatment aims to maintain an adequate cerebral blood flow with …

Cerebrovascular disease and trauma are leading causes of death in the United States. In
addition to the initial insult to the brain, disturbances of cerebral oxygenation and …

Brain ischemia (defined here as restricted flow) and/or hypoxia (defined here as a reduced
oxygen supply) caused by stroke is a major cause of death and debilitation. In addition …

Over the past 40 to 50 years, we have made strides in understanding the molecular
underpinnings of oxidative stress and its consequences in severe traumatic brain injury …

There is mounting evidence both from experimental and clinical studies that traumatic brain
injury (TBI) is associated with a reduction of aerobic metabolism. This results from a variable …

Objective To investigate the relationship between oxygenation and short-term outcomes in
patients with traumatic brain injury (TBI). Design Logistic regression analysis was used to …

Despite suggestive data from microdialysis studies, direct measurement of the ability of the
brain to utilize oxygen indicates that hyperoxia does not increase oxygen utilization. This …