Objective To determine whether vascular and neurodegenerative factors influence cognition
before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and …

Importance β-Amyloid (Aβ) deposition and vascular brain injury (VBI) frequently co-occur
and are both associated with cognitive decline in aging. Determining whether a direct …

Objective To develop, replicate, and validate an MRI-based quantitative measure of both
cerebrovascular and neurodegeneration in Alzheimer disease (AD) for clinical and …

Background and objectives Vascular risk factors and elevated β-amyloid (Aβ) are commonly
observed together among older adults. Here, we examined the interactive vs independent …

Importance Identifying asymptomatic individuals at high risk of impending cognitive decline
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …

We characterized the additive contribution of cerebrovascular biomarkers to amyloid and
neurodegeneration biomarkers (AV (N)) when modeling prospective, longitudinal cognitive …

Background/Objective: To determine the impact of vascular burden on rates of decline in
episodic memory and executive function. We hypothesize that greater vascular burden will …

Introduction Little is known about how antecedent vascular risk factor (VRF) profiles impact
late‐life brain health. Methods We examined baseline VRFs, and cognitive testing and …

While cerebrovascular disease can be observed in vivo using MRI, the multiplicity and
heterogeneity in the mechanisms of cerebrovascular damage impede accounting for these …

Objective: To investigate the vascular contribution to longitudinal changes in Alzheimer
disease (AD) biomarkers. Methods: The Alzheimer's Disease Neuroimaging Initiative is a …