Objective: Our aim was to test the association of vascular risk factor exposure in midlife with
progression of MRI markers of brain aging and measures of cognitive decline. Methods: A …

Abstract Background African Americans have been reported to have a higher prevalence of
Alzheimer's disease (AD) than Caucasians, but etiology-specific AD biomarkers have not …

Background: Vascular disease is associated with increased risk of dementia. Vascular
health worsens with age. We investigated the relationship between self-reported vascular …

Background and Purpose—The relationships between cerebrovascular lesions visible on
imaging and cognition are complex. We explored the possibility that the cerebral cortical …

Background and Purpose—Brain atrophy, cortical infarction, and subcortical ischemic
vasculopathy have all been associated with cognitive dysfunction. The interrelationships …

Objective Elevated vascular risk and beta‐amyloid (Aβ) burden have been synergistically
associated with cognitive decline in preclinical Alzheimer's disease (AD), although the …

Our primary objective was to investigate a biomarker driven model for the interrelationships
between vascular disease pathology, amyloid pathology, and longitudinal cognitive decline …

Alzheimer's disease (AD) is the most common cause of cognitive dysfunction in older adults.
The pathological hallmarks of AD such as beta amyloid (Aβ) aggregation and …

Background Current hypothetical models of Alzheimer's disease (AD) pathogenesis
emphasize the role of β-amyloid (Aβ), tau deposition, and neurodegenerative changes in the …

Cardiovascular disease (CVD) is associated with a higher risk of developing dementia.
Studies have found that vascular risk factors are associated with greater amyloid-β (Aβ) and …