Importance Cerebrovascular disease and Alzheimer disease (AD) frequently co-occur and
seem to act through different pathways in producing dementia. Objective To examine …

Introduction Vascular factors increase the risk of Alzheimer's disease (AD). We investigated
the associations between such factors, longitudinal AD cerebrospinal fluid biomarkers, and …

Objective To evaluate relationships between magnetic resonance imaging (MRI)–based
measures of white matter hyperintensities (WMHs), measured at baseline and longitudinally …

We investigated the effects of cardiovascular risk factors, such as hypertension, diabetes
mellitus, and hypercholesterolemia, on longitudinal regional cerebral blood flow (rCBF) …

To investigate patterns of hippocampal subfield atrophy among patients with amnestic mild
cognitive impairment, stratified by severity of small vessel disease (SVD) and corresponding …

Importance It remains unclear if and how associations between cerebral small-vessel
disease and Alzheimer disease (AD) pathology lead to cognitive decline and dementia …

Objective Given the potential therapeutic effect of vascular disease control timing to reduce
dementia risk, we investigated the age-related influences of vascular risk factor burden on …

Background: There is evidence that Alzheimer's disease (AD) has significant
cerebrovascular etiopathogenesis. Understanding potentially modifiable risk factors for …

The involvement of vascular factors in Alzheimer dementia was first appreciated over 100
years ago. Recently, significant advances in our understanding of these brain‐vascular …

Few studies have applied multiple imaging modalities to examine cognitive correlates of
white matter. We examined the utility of T2-weighted magnetic resonance imaging (MRI) …