Signal transducer and activator of transcription (STAT2) is a member of the STAT family that
plays an essential role in immune responses to extracellular and intracellular stimuli …

The Signal Transducer and Activator of Transcription (STAT)-5 proteins are required in
immune regulation and homeostasis and play a crucial role in the development and function …

The signal transducer and activator of transcription-2 (STAT2) was discovered as a cellular
component of the DNA binding complex known as interferon (IFN) stimulated gene factor-3 …

The tumor microenvironment consists of tumor cells, extracellular matrix, blood vessels, and
non-tumor cells such as fibroblasts and immune cells. Crosstalk among components of this …

STATs are a family of transcription factors that regulate many critical cellular processes such
as proliferation, apoptosis, and differentiation. Dysregulation of STATs is frequently …

The roles and significance of STAT3 in cancer biology have been extensively studied for
more than a decade. Mounting evidence has shown that constitutive activation of STAT3 is a …

STAT3 is both a transcription activator and an oncogene that is tightly regulated under
normal physiological conditions. However, abundant evidence indicates that STAT3 is …

The transcription factors STAT1 and STAT3 appear to play opposite roles in tumorigenesis.
While STAT3 promotes cell survival/proliferation, motility and immune tolerance and is …

Signal transducers and activators of transcription (STATs) are latent cytoplasmic
transcription factors that mediate various biological responses, including cell proliferation …

Recent evidence suggests that what sustains a tumor's survival and proliferation can also
subvert the immune system from its defense role. As a point of convergence for numerous …