In a double‐blind multicentre trial in patients with major depression, the efficacy and the
tolerability of sertraline were compared to those of imipramine, during an 8‐week acute …

Objective: To evaluate the efficacy, safety, and tolerability of fixed-dose agomelatine 25 and
50 mg/d in the treatment of outpatients with moderate-to-severe major depressive disorder …

Purpose The purpose of this study is to investigate the efficacy, safety, and tolerability of
agomelatine and paroxetine in Chinese Han patients with major depressive disorder (MDD) …

Objective The aim of this study was to compare the efficacy and tolerability of reboxetine in
the treatment of major depressive disorder (MDD) and MDD with anxiety features to …

Objective To examine how clinical and demographic patient baseline characteristics
influence effectiveness of duloxetine versus selective serotonin reuptake inhibitor (SSRI) …

Background: The comparative efficacy of selective serotonin reuptake inhibitors (SSRIs) and
serotoninnorepinephrine reuptake inhibitors (SNRIs) was recently debated. Meta-analyses …

This double-blind, randomized study evaluated the efficacy and safety of trazodone OAD
(once-a-day) in comparison with venlafaxine XR (extended-release) in 324 patients (166 …

Maintenance treatment for depression should be considered as a chronic disease
management programme. Several studies have reported that sertraline (SRT) can be useful …

Objective: This study looks to compare the antidepressant efficacy and safety of a
standardized extract of St John's wort with both placebo and fluoxetine. Method: After a 1 …

Objective: Agomelatine is a new antidepressant with unique melatonin receptor type 1A
(MTNR1A) and 1B (MTNR1B) agonism and serotonergic receptor 5-hydroxytryptamine …