Heart failure (HF) is a global pandemic with significant mortality and morbidity. Despite
current medications, 50% of individuals die within 5 years of diagnosis. Of these deaths, 30 …

Heart contraction vitally depends on tightly controlled intracellular Ca regulation. Because
contraction is mainly driven by Ca released from the sarcoplasmic reticulum (SR), this …

Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca 2+ …

The cardiac ryanodine receptor (RyR2), a Ca2+ release channel on the membrane of the
sarcoplasmic reticulum (SR), plays a key role in determining the strength of the heartbeat by …

Abstract Type 2 ryanodine receptor (RyR2) serves as the major intracellular Ca 2+ release
channel that drives heart contraction. RyR2 is activated by cytosolic Ca 2+ via the process of …

This Controversies in Research article discusses the hypothesis that protein kinase A (PKA)-
mediated phosphorylation of the Ryanodine Receptor (RyR) at a single serine (RyRS2808) …

Abnormal cardiac ryanodine receptor (RyR2) function is recognized as an important factor in
the pathogenesis of heart failure (HF). However, the specific molecular causes underlying …

Increased sarcoplasmic reticulum (SR) Ca2+ leak via the cardiac ryanodine
receptor/calcium release channel (RyR2) is thought to play a role in heart failure (HF) …

Heart failure (HF) is a chronic multi-factorial disease characterized by sarcoplasmic
reticulum (SR) dysfunction that manifests as severely reduced contractility and increased …

By the time the heart reaches the pathological state clinically recognized as heart failure
(HF), it has undergone profound and often irreversible alterations in structure and function at …