Introduction Colorectal cancer (CRC) is one of the most common and deadly tumors
worldwide. CRC in vitro and in vivo models that recapitulate key features of human disease …

Introduction: Despite increased screening rates and advances in targeted therapy, colorectal
cancer (CRC) remains the third leading cause of cancer-related mortality. CRC models that …

The process of drug discovery and pre‐clinical testing is currently inefficient, expensive, and
time‐consuming. Most importantly, the success rate is unsatisfactory, as only a small …

Colorectal cancer (CRC), the third most common cancer diagnosed in both men and women
in the United States, shows a highly ineffective therapeutic management. In these years …

Colorectal cancer (CRC) is a heterogeneous and molecularly complex disease, associated
with high mortality worldwide, exposing the urgent need for novel therapeutic approaches …

Colorectal cancer (CRC) is a heterogeneous disease. Conventional two-dimensional (2D)
culture employing cell lines was developed to study the molecular properties of CRC in vitro …

Colorectal cancer (CRC) is a leading cause of death worldwide. Improved preclinical tumor
models are needed to make treatment screening clinically relevant and address disease …

The majority of cancer-related in vitro studies are conducted on cell monolayers or
spheroids. Although this approach has led to key discoveries, it still has a poor outcome in …

Organoids have revolutionized cancer research as highly adaptable models that enable an
array of experimental techniques to interrogate tissue morphology and function. Because …

Cancer prognosis remains a lottery dependent on cancer type, disease stage at diagnosis,
and personal genetics. While investment in research is at an all‐time high, new drugs are …