Aging is associated with changes in spatial navigation behavior. In addition to an overall
performance decline, older adults tend to rely more on proximal location cue information …

Accumulated evidence from animal studies suggests a role for the neuromodulator
dopamine in memory processes, particularly under conditions of novelty or reward. Our …

Striatal dopamine depletion is a key pathophysiological feature of Parkinson's disease (PD)
causing motor and nonmotor symptoms. Research on nonmotor symptoms has mainly …

The neuroimaging literature has shown consistent decreases in functional magnetic
resonance imaging (fMRI) activity in the hippocampus of healthy older adults engaged in a …

Spatial navigation is a complex cognitive skill that is necessary for everyday functioning in
the environment. However, navigational skills are not typically measured in most test …

Older adults have difficulties in navigating unfamiliar environments and updating their
wayfinding behavior when faced with blocked routes. This decline in navigational …

Age-related decline in spatial navigation is well-known and the extant literature emphasizes
the important contributions of a hippocampus-dependent spatial navigation system in …

Healthy young adults use different strategies when navigating in a virtual maze. Spatial
strategies involve using environmental landmarks while response strategies involve …

The hippocampus is negatively affected by aging and is critical for spatial navigation. While
there is evidence that wayfinding navigation tasks are especially sensitive to preclinical …

Objective: Cognitive aging varies widely among individuals. Whereas optimal cognitive
agers show highly preserved cognitive functions throughout life, other subjects experience …