Epidermal growth factor receptor (EGFR) takes centre stage in carcinogenesis throughout its
entire cellular trafficking odyssey. When loaded in extracellular vesicles (EVs), EGFR is one …

Simple Summary Extracellular vesicles (EVs), consisting of microvesicles and exosomes,
serve as messengers for intercellular communication by transporting proteins and nucleic …

EGFR and some of the cognate ligands extensively traffic in extracellular vesicles (EVs) from
different biogenesis pathways. EGFR belongs to a family of four homologous tyrosine kinase …

Simple Summary Overexpression of the transmembrane protein, epidermal growth factor
receptor (EGFR), drives tumour progression in several cancers including breast, lung …

Signaling from the epidermal growth factor receptor (EGFR) elicits multiple biological
responses, including cell proliferation, migration, and survival. Receptor endocytosis and …

Epidermal growth factor receptor (EGFR) plays a significant role in promoting breast cancer
progression. However, targeting EGFR as a single treatment only resulted in moderate …

When cell surface receptors engage their cognate ligands in the extracellular space, they
become competent to transmit potent signals to the inside of the cell, thereby instigating …

Cancer cells emit extracellular vesicles (EVs) containing unique molecular signatures. Here,
we report that the oncogenic EGF receptor (EGFR) and its inhibitors reprogram …

Epidermal growth factor receptor (EGFR) is a prototype receptor tyrosine kinase and an
oncoprotein in many solid tumors. Cell surface display of EGFR is essential for cellular …

Epidermal growth factor (EGF) receptor (EGFR) signalling regulates diverse cellular
functions, promoting cell proliferation, differentiation, migration, cell growth and survival …