LEAP-2: an emerging endogenous ghrelin receptor antagonist in the pathophysiology of obesity
Liver-expressed antimicrobial peptide 2 (LEAP-2), originally described as an antimicrobial
peptide, has recently been recognized as an endogenous blocker of growth hormone …
peptide, has recently been recognized as an endogenous blocker of growth hormone …
Ghrelin and LEAP-2: rivals in energy metabolism
Liver-expressed antimicrobial peptide 2 (LEAP-2), the endogenous noncompetitive
allosteric antagonist of the growth hormone secretagogue receptor 1a (GHSR1a), was …
allosteric antagonist of the growth hormone secretagogue receptor 1a (GHSR1a), was …
LEAP-2 counteracts ghrelin-induced food intake in a nutrient, growth hormone and age independent manner
J Lugilde, S Casado, D Beiroa, J Cuñarro… - Cells, 2022 - mdpi.com
Data gleaned recently shows that ghrelin, a stomach derived peptide, and liver-expressed-
antimicrobial peptide 2 (LEAP-2) play opposite roles on food intake. However, the data …
antimicrobial peptide 2 (LEAP-2) play opposite roles on food intake. However, the data …
N-terminal liver-expressed antimicrobial peptide 2 (LEAP2) region exhibits inverse agonist activity toward the ghrelin receptor
C M'Kadmi, A Cabral, F Barrile, J Giribaldi… - Journal of Medicinal …, 2018 - ACS Publications
The ghrelin receptor or growth hormone secretagogue receptor (GHSR) is a G-protein-
coupled receptor that controls growth hormone and insulin secretion, food intake, and …
coupled receptor that controls growth hormone and insulin secretion, food intake, and …
Liver-expressed antimicrobial peptide 2 antagonizes the effect of ghrelin in rodents
Ghrelin, a stomach-derived peptide, promotes feeding and growth hormone (GH) secretion.
A recent study identified liver-expressed antimicrobial peptide 2 (LEAP2) as an endogenous …
A recent study identified liver-expressed antimicrobial peptide 2 (LEAP2) as an endogenous …
[HTML][HTML] LEAP2 is an endogenous antagonist of the ghrelin receptor
X Ge, H Yang, MA Bednarek, H Galon-Tilleman… - Cell metabolism, 2018 - cell.com
Ghrelin, an appetite-stimulatory hormone secreted by the stomach, was discovered as a
ligand for the growth hormone secretagogue receptor (GHSR). Through GHSR, ghrelin …
ligand for the growth hormone secretagogue receptor (GHSR). Through GHSR, ghrelin …
[HTML][HTML] LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue
Objective The hormone liver-expressed antimicrobial peptide-2 (LEAP2) is a recently
identified antagonist and an inverse agonist of the growth hormone secretagogue receptor …
identified antagonist and an inverse agonist of the growth hormone secretagogue receptor …
Identifying the binding mechanism of LEAP 2 to receptor GHSR 1a
JH Wang, HZ Li, XX Shao, WH Nie, YL Liu… - The FEBS …, 2019 - Wiley Online Library
Liver‐expressed antimicrobial peptide 2 (LEAP 2) is a highly conserved secretory peptide
first isolated in 2003. However, its exact biological functions remained elusive until a recent …
first isolated in 2003. However, its exact biological functions remained elusive until a recent …
A novel truncated liver enriched antimicrobial peptide-2 palmitoylated at its N-terminal antagonizes effects of ghrelin
L Holá, B Železná, A Karnošová, J Kuneš… - … of Pharmacology and …, 2022 - ASPET
Ghrelin is secreted in the stomach during fasting and targets the growth hormone
secretagogue receptor (GHSR1a) in the hypothalamus and brainstem to exert its orexigenic …
secretagogue receptor (GHSR1a) in the hypothalamus and brainstem to exert its orexigenic …
[HTML][HTML] LEAP2 reduces postprandial glucose excursions and ad libitum food intake in healthy men
CA Hagemann, MS Jensen, S Holm, LS Gasbjerg… - Cell Reports …, 2022 - cell.com
The gastric hormone ghrelin stimulates food intake and increases plasma glucose through
activation of the growth hormone secretagogue receptor (GHSR). Liver-expressed …
activation of the growth hormone secretagogue receptor (GHSR). Liver-expressed …