Neural induction constitutes the initial step in the generation of the vertebrate nervous
system. In attempting to understand the principles that underlie this process, two key issues …

▪ Abstract The formation of the vertebrate nervous system is initiated at gastrula stages of
development, when signals from a specialized cluster of cells (the organizer) trigger neural …

How does the vertebrate embryo make a nervous system? This complex question has been
at the center of developmental biology for many years. The earliest step in this process–the …

▪ Abstract During early vertebrate development, the cells of the ectoderm choose between
two possible fates: neural and epidermal. The process of neural induction was discovered …

In vertebrates, the development of the nervous system is triggered by signals from a
powerful 'organizing'region of the early embryo during gastrulation. This phenomenon …

During neural induction, the embryonic neural plate is specified and set aside from other
parts of the ectoderm. A popular molecular explanation is thedefault model'of neural …

Although the spatial and temporal orchestration of early vertebrate embryogenesis is
missing from cell culture systems, recent work suggests that many of the same signals …

Development of neural fates from ectoderm is accompanied by the blockage of BMP signals
at both protein and mRNA levels. Recent work has employed zebrafish, chick and mouse in …

The identification of genes in Xenopus, chick and zebrafish expressed early in prospective
neural crest (NC) cells has challenged the previous view that the NC is induced during the …

We have analyzed the transduction pathways involved in the triggering of neural induction,
in amphibian embryos, in vivo. Using a plasmid construction, we have targetted the …