Apoptosis in the fetal testis eliminates developmentally defective germ cell clones
Many germ cells are eliminated during development, long before oogenesis or
spermatogenesis. In mouse fetal testes, the majority of germ cell apoptosis coincides with …
spermatogenesis. In mouse fetal testes, the majority of germ cell apoptosis coincides with …
Primordial germ cell DNA demethylation and development require DNA translesion synthesis
P Shah, R Hill, C Dion, SJ Clark, A Abakir… - Nature …, 2024 - nature.com
Mutations in DNA damage response (DDR) factors are associated with human infertility,
which affects up to 15% of the population. The DDR is required during germ cell …
which affects up to 15% of the population. The DDR is required during germ cell …
Mouse differentiating spermatogonia can generate germinal stem cells in vivo
V Barroca, B Lassalle, M Coureuil, JP Louis… - Nature cell …, 2009 - nature.com
In adults, stem cells are responsible for the maintenance of many actively renewing tissues,
such as haematopoietic, skin, gut and germinal tissues. These stem cells can self-renew or …
such as haematopoietic, skin, gut and germinal tissues. These stem cells can self-renew or …
[HTML][HTML] In vitro reconstitution of epigenetic reprogramming in the human germ line
Y Murase, R Yokogawa, Y Yabuta, M Nagano, Y Katou… - Nature, 2024 - nature.com
Epigenetic reprogramming resets parental epigenetic memories and differentiates
primordial germ cells (PGCs) into mitotic pro-spermatogonia or oogonia. This process …
primordial germ cells (PGCs) into mitotic pro-spermatogonia or oogonia. This process …
Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte
Gametes are highly specialized cells that can give rise to the next generation through their
ability to generate a totipotent zygote. In mice, germ cells are first specified in the developing …
ability to generate a totipotent zygote. In mice, germ cells are first specified in the developing …
Germ cell reprogramming
K Kurimoto, M Saitou - Current Topics in Developmental Biology, 2019 - Elsevier
Germ cells undergo epigenome reprogramming for proper development of the next
generation. The achievement of in vitro germ cell derivation from human and mouse …
generation. The achievement of in vitro germ cell derivation from human and mouse …
Pluripotency of spermatogonial stem cells from adult mouse testis
Embryonic germ cells as well as germline stem cells from neonatal mouse testis are
pluripotent and have differentiation potential similar to embryonic stem cells,, suggesting that …
pluripotent and have differentiation potential similar to embryonic stem cells,, suggesting that …
Uncovering gene regulatory networks during mouse fetal germ cell development
AD Rolland, KP Lehmann, KJ Johnson… - Biology of …, 2011 - academic.oup.com
The commitment of germ cells to either oogenesis or spermatogenesis occurs during fetal
gonad development: germ cells enter meiosis or mitotic arrest, depending on whether they …
gonad development: germ cells enter meiosis or mitotic arrest, depending on whether they …
Epigenetic events in mammalian germ-cell development: reprogramming and beyond
The epigenetic profile of germ cells, which is defined by modifications of DNA and
chromatin, changes dynamically during their development. Many of the changes are …
chromatin, changes dynamically during their development. Many of the changes are …
Male germ cell apoptosis: regulation and biology
C Shaha, R Tripathi, DP Mishra - … Transactions of the …, 2010 - royalsocietypublishing.org
Cellular apoptosis appears to be a constant feature in the adult testis and during early
development. This is essential because mammalian spermatogenesis is a complex process …
development. This is essential because mammalian spermatogenesis is a complex process …