Spermatogenesis constitutes a remarkable program of cell differentiation, which involves
dramatic changes in cell morphology, biochemistry and gene expression1, 2. But the study …

Germ cell fate in mice is induced in proximal epiblast cells by the extra-embryonic ectoderm,
and is not acquired through the inheritance of any preformed germ plasm. To determine …

Induction of mouse germ cells occurs from the proximal epiblast at around embryonic day
(E) 7.0. These germ cells then migrate to, and enter the gonads at about E10. 5 after which …

Spermatogenesis is a truly remarkable process that requires exquisite control and
synchronization of germ cell development. It is prone to frequent error, as paternal infertility …

Spermatogonial stem and progenitor cells (SSCs) generate adult male gametes. During in
vitro expansion, these unipotent murine cells spontaneously convert to multipotent adult …

Background Spermatogonial stem cell transplantation (SSCT) is proposed as a fertility
therapy for childhood cancer survivors. SSCT starts with cryopreserving a testicular biopsy …

During mouse development, primordial germ cells (PGCs) that give rise to the entire germ
line are first identified within the proximal epiblast. However, long-term tracing of the fate of …

Germ cells undergo comprehensive epigenetic reprogramming toward acquiring fitness for
pluripotency and totipotency. Notably, the full extent of the epigenetic reprogramming …

Background Epigenetic reprogramming is a critical step in male germ cell development that
occurs during perinatal life. It is characterized by the remodeling of different epigenetic …

Epigenetic reprogramming is a central process during mammalian germline development.
Genome-wide DNA demethylation in primordial germ cells (PGCs) is a prerequisite for the …