Fundamentally different recombination defects cause apoptosis of mouse spermatocytes at
the same stage in development, stage IV of the seminiferous epithelium cycle, equivalent to …

In mammals, both parental genomes undergo dramatic epigenetic changes after fertilization
to form the diploid somatic genome. Here we show that the paternal genome in the mouse is …

Germline de novo mutations are the basis of evolutionary diversity but also of genetic
disease. However, the molecular origin, mechanisms and timing of germline mutagenesis …

The germ-cell lineage ensures the continuity of life through the generation of male and
female gametes, which unite to form a totipotent zygote. We have previously demonstrated …

The ability of adult stem cells to reside in a quiescent state is crucial for preventing
premature exhaustion of the stem cell pool. However, the intrinsic epigenetic factors that …

In mice, epiblast cells found both the germ-line and somatic lineages in the developing
embryo. These epiblast cells carry epigenetic information from both parents that is required …

Sperm are highly differentiated and the activities that reprogram them for embryonic
development during fertilization have historically been considered unique to the oocyte. We …

Background In the male germline, neonatal prospermatogonia give rise to spermatogonia,
which include stem cell population (undifferentiated spermatogonia) that supports …

Germ cell degeneration is common in mammalian testes during the developmental as well
as the adult period. To investigate the extent and mechanisms of male germ cell death …

Background information. Primordial germ cells in developing male and female gonads are
responsive to somatic cell cues that direct their sex‐specific differentiation into functional …