The testis produces gametes through spermatogenesis and evolves rapidly at both the
morphological and molecular level in mammals,,,,–, probably owing to the evolutionary …

Epigenetic reprogramming in the germline provides a developmental model to study the
erasure of epigenetic memory as it occurs naturally in vivo in the course of normal …

Gonadal development is a complex process that involves sex determination followed by
divergent maturation into either testes or ovaries. Historically, limited tissue accessibility, a …

Although stem cells are believed to divide infinitely by self-renewal division, there is little
evidence that demonstrates their infinite replicative potential. Spermatogonial stem cells are …

The initial cohort of mammalian gametes is established by the proliferation of primordial
germ cells in the early embryo. Primordial germ cells first appear in extraembyronic tissues …

Germ cells are unique in engendering totipotency, yet the mechanisms underlying this
capacity remain elusive. Here, we perform comprehensive and in‐depth nucleome analysis …

Germ cell development is controlled by unique gene expression programs and involves
epigenetic reprogramming of histone modifications and DNA methylation. The central event …

The rarity and inaccessibility of the earliest primordial germ cells (PGCs) in the mouse
embryo thwart efforts to investigate molecular mechanisms of germ-cell specification. stella …

Animal germline cells ultimately produce eggs and sperm, providing an immortal link to the
next generation. Establishing and maintaining the germline requires a conserved gene set …

Genome sequencing studies of de novo mutations in humans have revealed surprising
incongruities in our understanding of human germline mutation. In particular, the mutation …