Brüne's proposal that erstwhile'vulnerability'genes need to be reconsidered as'
plasticity'genes, given the potential for certain environments to yield increased positive …

Racism is a chronic stressor fueled by stigma that can result in significant distress and
dysfunction as well as negatively affect emotions, behavior, quality of life, and brain health …

Existing literature provides extended evidence of the close relationship between stress
dysregulation, environmental insults, and psychosis onset. Early stress can sensitize …

Comprehensive clinical studies show that adverse conditions in early life can severely
impact the developing brain and increase vulnerability to mood disorders later in life. During …

Lifelong indices of maladaptive behavior or illness often stem from early physiological
aberrations during periods of dynamic development. This is especially true when …

This Comment highlights the intertwined nature of mental and brain health and disease.
Common genetic, environmental and lifestyle factors contribute to psychiatric and …

The impact that stressful encounters have upon long-lasting behavioural phenotypes is
varied. Whereas a significant proportion of the population will develop “stress-related” …

Early adverse experiences are associated with heighted vulnerability for stress-related
psychopathology across the lifespan. While extensive work has investigated the effects of …

Childhood adversity can have life-long consequences for the response to stressful events
later in life. Abuse or severe neglect are well-known risk factors for post-traumatic stress …

The development of mental disorders constitutes a complex phenomenon driven by unique
social, psychological and biological factors such as genetics and epigenetics, throughout an …