Age-related loss of activity of auditory-nerve fibers

RA Schmiedt, JH Mills… - Journal of …, 1996 - journals.physiology.org
1. Characteristic frequencies (CF), spontaneous rates (SR), and thresholds were recorded
from single fibers in the auditory nerves of gerbils aged for 36 mo in a quiet vivarium. The …

[HTML][HTML] Cellular mechanisms of noise-induced hearing loss

A Kurabi, EM Keithley, GD Housley, AF Ryan… - Hearing research, 2017 - Elsevier
Exposure to intense sound or noise can result in purely temporary threshold shift (TTS), or
leave a residual permanent threshold shift (PTS) along with alterations in growth functions of …

[HTML][HTML] Primary neural degeneration in the Guinea pig cochlea after reversible noise-induced threshold shift

HW Lin, AC Furman, SG Kujawa… - Journal of the Association …, 2011 - Springer
Recent work in mouse showed that acoustic overexposure can produce a rapid and
irreversible loss of cochlear nerve peripheral terminals on inner hair cells (IHCs) and a slow …

Cortical encoding of speech acoustics: Effects of noise and amplification

A Kuruvilla-Mathew, SC Purdy… - International journal of …, 2015 - Taylor & Francis
Objective: To investigate speech stimuli and background-noise-dependent changes in
cortical auditory-evoked potentials (CAEPs) in unaided and aided conditions, and determine …

[HTML][HTML] Inner hair cell ribbon synapse plasticity might be molecular basis of temporary hearing threshold shifts in mice

H Wang, N Zhao, K Yan, X Liu, Y Zhang… - … Journal of Clinical …, 2015 - ncbi.nlm.nih.gov
Recent studies have reported that noise exposure at relatively low intensities can cause
temporary threshold shifts (TTS) in hearing. However, the mechanism underlying the TTS is …

[HTML][HTML] Cochlear synaptopathy changes sound-evoked activity without changing spontaneous discharge in the mouse inferior colliculus

LA Shaheen, MC Liberman - Frontiers in systems neuroscience, 2018 - frontiersin.org
Tinnitus and hyperacusis are life-disrupting perceptual abnormalities that are often
preceded by acoustic overexposure. Animal models of overexposure have suggested a link …

[HTML][HTML] Noise-induced cochlear synaptopathy and signal processing disorders

H Chen, L Shi, L Liu, S Yin, S Aiken, J Wang - Neuroscience, 2019 - Elsevier
Noise-induced hidden hearing loss (NIHHL) has attracted great attention in hearing
research and clinical audiology since the discovery of significant noise-induced synaptic …

[HTML][HTML] Effects of age on psychophysical measures of auditory temporal processing and speech reception at low and high levels

S Carcagno, CJ Plack - Hearing research, 2021 - Elsevier
Age-related cochlear synaptopathy (CS) has been shown to occur in rodents with minimal
noise exposure, and has been hypothesized to play a crucial role in age-related hearing …

Dopaminergic and cholinergic innervation in the mouse cochlea after noise-induced or age-related synaptopathy

KE Grierson, TT Hickman, MC Liberman - Hearing Research, 2022 - Elsevier
Cochlear synaptopathy, the loss of or damage to connections between auditory-nerve fibers
(ANFs) and inner hair cells (IHCs), is a prominent pathology in noise-induced and age …

[HTML][HTML] Noise-induced and age-related hearing loss: new perspectives and potential therapies

MC Liberman - F1000Research, 2017 - ncbi.nlm.nih.gov
The classic view of sensorineural hearing loss has been that the primary damage targets are
hair cells and that auditory nerve loss is typically secondary to hair cell degeneration …