[HTML][HTML] Age-associated remodeling of T cell immunity and metabolism
Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …
The clock is ticking: the impact of ageing on T cell metabolism
It is now clear that access to specific metabolic programmes controls the survival and
function of various immune cell populations, including T cells. Efficient naïve and memory T …
function of various immune cell populations, including T cells. Efficient naïve and memory T …
Aging of the immune system. Mechanisms and therapeutic targets
CM Weyand, JJ Goronzy - Annals of the American Thoracic Society, 2016 - atsjournals.org
Beginning with the sixth decade of life, the human immune system undergoes dramatic
aging-related changes, which continuously progress to a state of immunosenescence. The …
aging-related changes, which continuously progress to a state of immunosenescence. The …
Mitochondrial metabolism in T cell activation and senescence: a mini-review
N Ron-Harel, AH Sharpe, MC Haigis - Gerontology, 2015 - karger.com
The aging immune system is unable to optimally respond to pathogens and generate long-
term immunological memory against encountered antigens. Amongst the immune …
term immunological memory against encountered antigens. Amongst the immune …
Metabolic regulation of T cell longevity and function in tumor immunotherapy
RJ Kishton, M Sukumar, NP Restifo - Cell metabolism, 2017 - cell.com
Cancer immunotherapy is an increasingly successful strategy for the treatment of patients
who have advanced or conventional therapy-resistant cancers. T cells are key mediators of …
who have advanced or conventional therapy-resistant cancers. T cells are key mediators of …
The effects of age and systemic metabolism on anti-tumor T cell responses
JM Drijvers, AH Sharpe, MC Haigis - Elife, 2020 - elifesciences.org
Average age and obesity prevalence are increasing globally. Both aging and obesity are
characterized by profound systemic metabolic and immunologic changes and are cancer …
characterized by profound systemic metabolic and immunologic changes and are cancer …
Defective respiration and one-carbon metabolism contribute to impaired naive T cell activation in aged mice
N Ron-Harel, G Notarangelo… - Proceedings of the …, 2018 - National Acad Sciences
T cell-mediated immune responses are compromised in aged individuals, leading to
increased morbidity and reduced response to vaccination. While cellular metabolism tightly …
increased morbidity and reduced response to vaccination. While cellular metabolism tightly …
Emerging concepts of T cell metabolism as a target of immunotherapy
CH Chang, EL Pearce - Nature immunology, 2016 - nature.com
T cells have a pivotal protective role in defense against infection and cancer but also are
instrumental in the development of many autoimmune diseases. The regulation of nutrient …
instrumental in the development of many autoimmune diseases. The regulation of nutrient …
Unraveling the complex interplay between T cell metabolism and function
RI Klein Geltink, RL Kyle… - Annual review of …, 2018 - annualreviews.org
Metabolism drives function, on both an organismal and a cellular level. In T cell biology,
metabolic remodeling is intrinsically linked to cellular development, activation, function …
metabolic remodeling is intrinsically linked to cellular development, activation, function …
Metabolic programs tailor T cell immunity in viral infection, cancer, and aging
SH Møller, PC Hsueh, YR Yu, L Zhang, PC Ho - Cell metabolism, 2022 - cell.com
Productive T cell responses to infection and cancer rely on coordinated metabolic
reprogramming and epigenetic remodeling among the immune cells. In particular, T cell …
reprogramming and epigenetic remodeling among the immune cells. In particular, T cell …