The high energy demands of the heart are met primarily by the mitochondrial oxidation of
fatty acids and glucose. However, in heart failure there is a decrease in cardiac …

During conditions that result in depleted circulating glucose levels, ketone bodies
synthesized in the liver are necessary fuel substrates for the brain. In other organs, such as …

Background: Accumulating evidence suggests that the failing heart reprograms fuel
metabolism toward increased utilization of ketone bodies and that increasing cardiac ketone …

Despite existing therapy, patients with heart failure (HF) experience substantial morbidity
and mortality, highlighting the urgent need to identify novel pathophysiological mechanisms …

The ketone bodies beta-hydroxybutyrate and acetoacetate are hepatically produced
metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and …

Ketone bodies can become a major source of adenosine triphosphate production during
stress to maintain bioenergetic homeostasis in the brain, heart, and skeletal muscles. In the …

Heart failure is a systemic disease in which both myocardium and skeletal muscle exhibit
alterations of energy metabolism. Failing myocardium exhibits impaired utilization of free …

The increased metabolic activity of the heart as a pump involves a high demand of
mitochondrial adenosine triphosphate (ATP) production for its mechanical and electrical …

Objectives. The present study was designed to assess whether blood ketone bodies are
elevated in congestive heart failure (CHF) and whether ketonemia is related to the …

Accumulating evidence suggests that the failing heart reverts energy metabolism toward
increased utilization of ketone bodies. Despite many discrepancies in the literature …