Hypoxia stabilizes hypoxia-inducible factors (HIFs), facilitating adaptation to hypoxic
conditions. Appropriate hypoxia is pivotal for neurovascular regeneration and immune cell …

J. Neurochem.(2010) 112, 1–12. Abstract Neurodegenerative diseases, generally
characterized by a progressive deterioration in the structure and function of the brain …

Abstract Hypoxia-inducible factor-1 (HIF-1) is a heterodimer protein composed of an oxygen-
regulated functional subunit, HIF-1α, and a structural subunit, HIF-1β, belonging to the basic …

A divergence in the supply and consumption of oxygen in brain tissue initiates complex
cycle of biochemical and molecular events resulting in neuronal death. To overcome such …

Hypoxia inducible factor-1 (HIF-1) is a transcriptional factor responsible for cellular and
tissue adaption to low oxygen tension. HIF-1, a heterodimer consisting of a constitutively …

Cerebral ischemia is the third leading cause of death in industrialized countries and an
important health system problem with no efficient treatment to date. The reduction in oxygen …

The objectives of this present work were to review recent developments on the role of
hypoxia‐inducible factor (HIF) in the survival of cells under normoxic versus hypoxic and …

Hypoxia is one of the most common pathological conditions, which can be induced by
multiple events, including ischemic injury, trauma, inflammation, tumors, etc. The body's …

In stroke research, a significant focus is to develop therapeutic strategies that prevent
neuronal death and improve recovery. Yet, few successful therapeutic strategies have …

Hypoxia-inducible factor-1α (HIF-1α) plays an essential role in cellular and systemic O2
homeostasis by regulating the expression of genes important in glycolysis, erythropoiesis …