Hippocampal metabolic recovery as a manifestation of the protective effect of ischemic preconditioning in rats

E Baranovicova, D Kalenska, M Kovalska… - Neurochemistry …, 2022 - Elsevier
The ever-present risk of brain ischemic events in humans and its full prevention make the
detailed studies of an organism's response to ischemia at different levels essential to …

Metabolomic recovery as a result of ischemic preconditioning was more pronounced in hippocampus than in cortex that appeared more sensitive to metabolomic …

E Baranovicova, D Kalenska, M Grendar, J Lehotsky - Metabolites, 2021 - mdpi.com
The study of an organism's response to ischemia at different levels is essential to
understand the mechanism of the injury as well as protection. We used the occlusion of four …

3-Nitropropionic acid-induced ischemia tolerance in the rat brain is mediated by reduced metabolic activity and cerebral blood flow

O Bracko, VD Pietro, G Lazzarino… - Journal of Cerebral …, 2014 - journals.sagepub.com
Tissue tolerance to ischemia can be achieved by noxious stimuli that are below a threshold
to cause irreversible damage ('preconditioning'). Understanding the mechanisms underlying …

Proteomic analysis of mouse brain cortex identifies metabolic down‐regulation as a general feature of ischemic pre‐conditioning

G Scornavacca, R Gesuete, F Orsini… - Journal of …, 2012 - Wiley Online Library
J. Neurochem.(2012) 122, 1219–1229. Abstract The molecular mechanisms that lead to
ischemic pre‐conditioning are not completely understood, and proteins are important …

Effect of antioxidant treatment in global ischemia and ischemic postconditioning in the rat hippocampus

I Domoráková, E Mechírová, M Danková… - Cellular and molecular …, 2009 - Springer
Ischemic postconditioning is a very effective way how to prevent delayed neuronal death.
Effect of Ginkgo biloba extract (EGb 761; 40 mg/kg) posttreatment was studied on the rat …

Ischemic preconditioning in the rat hippocampus increases antioxidant activities but does not affect the level of hydroxyl radicals during subsequent severe ischemia

YS Choi, KO Cho, EJ Kim, KW Sung… - Experimental & molecular …, 2007 - nature.com
Several studies have demonstrated that ischemic preconditioning increases superoxide
dismutase activity, but it is unclear how ischemic preconditioning affects events downstream …

Role of protein synthesis in the ischemic tolerance acquisition induced by transient forebrain ischemia in the rat

J Burda, M Hrehorovská, LG Bonilla… - Neurochemical …, 2003 - Springer
Although ischemic preconditioning of the heart and brain is a well-documented
neuroprotective phenomenon, the mechanism underlying the increased resistance to severe …

Brain ischemic preconditioning is abolished by antioxidant drugs but does not up-regulate superoxide dismutase and glutathion peroxidase

F Puisieux, D Deplanque, H Bulckaen, P Maboudou… - Brain research, 2004 - Elsevier
The present work examined the hypothesis that brain ischemic tolerance induced by
ischemic preconditioning (IPC) is triggered by an initial oxidative stress and is associated …

Ischemic preconditioning ameliorates excitotoxicity by shifting glutamate/γ‐aminobutyric acid release and biosynthesis

KR Dave, C Lange‐Asschenfeldt… - Journal of …, 2005 - Wiley Online Library
Excitotoxicity is recognized to play a major role in cerebral ischemia‐induced cell death. The
main goal of the present study was to define whether our model of ischemic preconditioning …

Oxygen free radicals and ischaemic preconditioning in the brain: preliminary data and a hypothesis

P Schumann, K Prass, F Wiegand, M Ahrens… - … in Cerebral Ischemia III …, 1999 - Springer
The mechanisms by which a sublethal preconditioning stress increases the resistance of the
brain to a subsequent ischaemic event are not fully elucidated. This phenomenon seems to …