Simple Summary Fiber pathways that descend from the brain to the spinal cord drive motor
behavior and modulate incoming sensory signals and the capacity to change (plasticity). A …

Abstract Changes in descending serotonergic innervation of spinal neural activity have been
implicated in symptoms of paralysis, spasticity, sensory disturbances and pain following …

Over the past 40 years, much has been learned about the role of serotonin in spinal cord
reflex modulation and locomotor pattern generation. This review presents an historical …

Following spinal cord injury (SCI) a series of anatomical and functional plastic changes
occurinthespinalcord, includingreorganizationofthespinalneuronal…, alteration of properties …

Spinal cord injury (SCI) is a tragic event causing irreversible losses of sensory, motor, and
autonomic functions, that may also be associated with chronic neuropathic pain. Serotonin …

Serotonin (5-HT), a monoamine neurotransmitter synthesized in various populations of
brainstem neurons, plays an important role in modulating the activity of spinal networks …

In animals, the recovery of motoneuron excitability in the months following a complete spinal
cord injury is mediated, in part, by increases in constitutive serotonin (5-HT2) and …

The area of spinal cord plasticity has become a very actively researched field. The spinal
cord has long been known to organize reflex patterns and serve as the major transmission …

Activation of receptors by serotonin (5-HT1) and norepinephrine (α2) on primary afferent
terminals and excitatory interneurons reduces transmission in spinal sensory pathways …

▪ Abstract Activity-dependent plasticity occurs in the spinal cord throughout life. Driven by
input from the periphery and the brain, this plasticity plays an important role in the …