Reassessing the role of eosinophils as a biomarker in chronic obstructive pulmonary disease

M Tinè, D Biondini, U Semenzato, E Bazzan… - Journal of clinical …, 2019 - mdpi.com
Blood eosinophils measurement, as proxy for tissue eosinophils, has become an important
biomarker for exacerbation risk and response to inhaled corticosteroids (ICS) in Chronic …

[HTML][HTML] Blood eosinophil levels as a biomarker in COPD

G Brusselle, ID Pavord, S Landis, S Pascoe, S Lettis… - Respiratory …, 2018 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder and patients
respond differently to treatment. Blood eosinophils are a potential biomarker to stratify …

Blood eosinophils as a biomarker of future COPD exacerbation risk: pooled data from 11 clinical trials

D Singh, JA Wedzicha, S Siddiqui, A de la Hoz… - Respiratory …, 2020 - Springer
Background Chronic obstructive pulmonary disease (COPD) is characterised by progressive
airflow limitation and chronic inflammation. Predicting exacerbations of COPD, which …

Relationship of blood eosinophil count to exacerbations in chronic obstructive pulmonary disease

RS Zeiger, TN Tran, RK Butler, M Schatz, Q Li… - The Journal of Allergy …, 2018 - Elsevier
Background Eosinophilic airway inflammation characterizes a chronic obstructive pulmonary
disease (COPD) phenotype that requires more study. Objective To investigate the …

Role of eosinophils in airway inflammation of chronic obstructive pulmonary disease

DP Tashkin, ME Wechsler - International journal of chronic …, 2018 - Taylor & Francis
COPD is a significant cause of morbidity and mortality. In some patients with COPD,
eosinophils contribute to inflammation that promotes airway obstruction; approximately a …

Circulating eosinophil levels do not predict severe exacerbations in COPD: a retrospective study

Y Adir, O Hakrush, M Shteinberg, S Schneer… - ERJ open …, 2018 - Eur Respiratory Soc
Whether the level of circulating eosinophils in chronic obstructive pulmonary disease
(COPD) patients can predict the risk of exacerbations of COPD (ECOPD) or response to …

Blood eosinophil and risk of exacerbation in chronic obstructive pulmonary disease patients: a retrospective cohort analysis

MC Chan, YC Yeung, ELM Yu… - International journal of …, 2020 - Taylor & Francis
Purpose Blood eosinophil is a readily available biomarker to reflect the eosinophilic
inflammation in chronic obstructive pulmonary disease (COPD) patients, yet its association …

Eosinophilic inflammation in COPD: from an inflammatory marker to a treatable trait

B David, M Bafadhel, L Koenderman, A De Soyza - Thorax, 2021 - thorax.bmj.com
The heterogeneity of chronic obstructive pulmonary disease (COPD) creates many
diagnostic, prognostic, treatment and management challenges, as the pathogenesis of …

Blood eosinophils: a biomarker of COPD exacerbation reduction with inhaled corticosteroids

SH Siddiqui, ID Pavord, NC Barnes… - … journal of chronic …, 2018 - Taylor & Francis
Background Growing evidence suggests that blood eosinophil count is associated with
patient responsiveness to inhaled corticosteroids (ICS). We performed post hoc predictive …

Blood eosinophil counts in COPD patients compared to controls

U Kolsum, T Southworth, N Jackson… - European Respiratory …, 2019 - Eur Respiratory Soc
In patients with COPD, blood eosinophil counts can predict the effects of inhaled
corticosteroids (ICS) on exacerbation rates [1–4]. Blood eosinophil counts are now …