Abstract Purpose We reevaluated the Action for Health in Diabetes (Look AHEAD) intensive
lifestyle intervention (ILI) to assess whether the effect of ILI on cardiovascular disease (CVD) …

The idea of precision medicine in the context of disease prevention is predicated on the
failure of standard approaches to adequately slow or prevent disease onset in many people …

OBJECTIVE We reevaluated the Action for Health in Diabetes (Look AHEAD) intervention,
incorporating diabetes subgroups, to identify whether intensive lifestyle intervention (ILI) is …

Background Lifestyle interventions produce short-term improvements in glycemia and
cardiovascular disease (CVD) risk factors in individuals with type 2 diabetes mellitus, but no …

Objective The Action for Health in Diabetes (Look AHEAD) trial was a randomized trial
comparing effects of intensive lifestyle intervention (ILI) and diabetes support and education …

Objective To examine the effects of an intensive lifestyle intervention (ILI) on cardiovascular
disease (CVD), the Action for Health in Diabetes (Look AHEAD) trial randomized 5,145 …

Background Because lifestyle-induced improvements in cardiovascular risk factors vary
substantially across individuals with type 2 diabetes, we investigated the extent to which …

We previously reported that maintenance of significant weight loss for up to 5 years was
attainable in real-world clinical practice among patients with diabetes and obesity and had a …

Background An association between variability of cardiovascular risk factors and
cardiovascular events has been reported. We examined whether intensive lifestyle …

Objective This study aimed to estimate the risk of cardiovascular disease (CVD) among
patients with and without diabetes mellitus (DM) using the Framingham risk score (FRS) and …