Aging of mice is associated with a change in CD8 T-cell subpopulations: While naïve CD8 T
cells (TN) decline, cells of the memory compartment (Tmem) accumulate in old mice. Little is …

Age-associated decreases in primary CD8+ T cell responses occur, in part, due to direct
effects on naive CD8+ T cells to reduce intrinsic functionality, but the precise nature of this …

CD4 T cells, and especially T follicular helper cells, are critical for the generation of a robust
humoral response to an infection or vaccination. Importantly, immunosenescence affects …

Ageing, in both mice and humans, results in the replacement of naive T cells by memory T
cells. Chiu et al. now show that virtual memory CD8+ T cells, which are unprimed memory …

Mitigating effects of aging on human health remains elusive because aging impacts multiple
systems simultaneously, and because experimental animals exhibit critical aging differences …

To uncouple the defects of activation and apoptosis of T cells from aged mice, we used anti-
CD3 plus IL-2 stimulation to induce an activation response and analyzed the subsequent …

Background CD4+ T cells can be broadly divided into naïve and memory subsets, each of
which are differentially impaired by the aging process. It is unclear if and how these …

CD4+ T cells regulate humoral and cell-mediated immune responses, which are
progressively impaired in aging, resulting in susceptibility to infections and cancer. Dendritic …

The mechanisms responsible for the diminished immune response seen with aging are
unclear. In this study, we investigate the contributions of alterations in the lymphoid …

Aging leads to alterations in the immune system that result in ineffective responsiveness
against pathogens. Features of this process, collectively known as immunosenescence …