Mucus clearance, a primary innate defense mechanism of airways, is defective in patients
with cystic fibrosis (CF) and CF animals. In previous work, the combination of a low dose of …

Mucociliary clearance (MCC) is a critical host innate defense mechanism in airways, and it is
impaired in cystic fibrosis (CF) and other obstructive lung diseases. Epithelial fluid secretion …

The beneficial effect of anticholinergic therapy for chronic lung diseases such as chronic
obstructive pulmonary disease (COPD) is well documented, although cholinergic stimulation …

Mucociliary clearance is an important primary innate defense mechanism that protects the
lungs from deleterious effects of inhaled pollutants, allergens, and pathogens. Mucociliary …

Cystic fibrosis (CF) airway disease is characterized by excessive and accumulative mucus in
the airways. Mucociliary clearance becomes defective as mucus secretions become …

In cystic fibrosis (CF), whether cystic fibrosis transmembrane conductance regulator (CFTR)
dysfunction leads to decreased mucociliary clearance and mucus hypersecretion, before …

Rationale: Cystic fibrosis is a genetic disorder characterized by recurrent airway infections,
inflammation, and progressive decline in lung function. Autopsy and spirometry data suggest …

Cystic fibrosis (CF) lung disease is the major cause of morbidity and mortality in people with
CF. Abnormal mucociliary transport has been the leading hypothesis for the underlying …

Lung disease in people with cystic fibrosis (CF) is initiated by defective host defense that
predisposes airways to bacterial infection. Advanced CF is characterized by a deficit in …

In cystic fibrosis (CF), the loss of cystic fibrosis transmembrane conductance regulator
(CFTR) mediated Cl− and HCO3− secretion across the epithelium acidifies the airway …