The respiratory epithelium is highly complex, and its composition varies along the
conducting airways and alveoli. In addition to their primary function in maintaining the …

Respiratory epithelia fulfil multiple roles beyond that of gaseous exchange, also acting as
primary custodians of lung sterility and inflammatory homeostasis. Inhaled fungal spores …

Aspergillus fumigatus is an environmental filamentous fungus that can be pathogenic for
humans, wherein it is responsible for a large variety of clinical forms ranging from allergic …

The lung epithelial lining serves as the primary barrier to inhaled environmental toxins,
allergens, and invading pathogens. Pulmonary fungal infections are devastating and carry …

Aspergillus fumigatus is an opportunistic environmental mold that can cause severe allergic
responses in atopic individuals and poses a life-threatening risk for severely …

Highlights•The lung epithelium orchestrates immune responses to inhaled fungi or their
constituents.•Lung epithelium represents a 'tipping point'shaping protective or pathological …

Aspergillus fumigatus is the most important mould pathogen in immunosuppressed patients.
Suboptimal clearance of inhaled spores results in the colonisation of the lung airways by …

Mycotic infections and their effect on the human condition have been widely overlooked and
poorly surveilled by many health organizations even though mortality rates have increased …

Invasive aspergillosis is a major cause of morbidity and mortality in highly
immunocompromised patients with cancer. Alveolar macrophages ingest inhaled conidia …

Fungal infections are estimated to be the main cause of death for more than 1.5 million
people worldwide annually. However, fungal pathogenicity has been largely neglected. This …