We characterized the additive contribution of cerebrovascular biomarkers to amyloid and
neurodegeneration biomarkers (AV (N)) when modeling prospective, longitudinal cognitive …

Objective To determine whether vascular and neurodegenerative factors influence cognition
before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and …

Introduction Little is known about how antecedent vascular risk factor (VRF) profiles impact
late‐life brain health. Methods We examined baseline VRFs, and cognitive testing and …

In addition to amyloid and tau pathology, elevated systemic vascular risk, white matter injury,
and reduced cerebral blood flow contribute to late-life cognitive decline. Given the strong …

Importance Identifying asymptomatic individuals at high risk of impending cognitive decline
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …

Our primary objective was to investigate a biomarker driven model for the interrelationships
between vascular disease pathology, amyloid pathology, and longitudinal cognitive decline …

Introduction AD and CVD, which frequently co-occur, are leading causes of age-related
cognitive decline. We assessed how demographic factors, socioeconomic status (SES) as …

Alzheimer's disease (AD) is the most common cause of cognitive dysfunction in older adults.
The pathological hallmarks of AD such as beta amyloid (Aβ) aggregation and …

Objective: American Indians experience substantial health disparities relative to the US
population, including vascular brain aging. Poorer cognitive test performance has been …

Background: Black Americans are approximately twice as likely to develop dementia as
compared to White Americans and the magnitude of this disparity is often attributed to a …