Paramagnetic metals can induce T1 shortening by interaction with free water molecules.
Two metal ions, Gadolinium and Manganese, are currently available for human use …

Gadolinium-based MRI contrast agents (CAs) can be effective at a∼ 100-fold lower
concentration of Gadolinium ions in comparison to the concentration of Iodine atoms …

Numerous macromolecular MRI contrast agents prepared employing relatively simple
chemistry may be readily available that can provide sufficient enhancement for multiple …

We have developed a new class of magnetic resonance imaging contrast agents with large
proton relaxation enhancements and high molecular relaxivities. The reagents are built from …

Dendritic gadolinium chelates as magnetic resonance imaging (MRI) contrast agents (CAs)
have shown great potential in blood pool and tumor imaging due to their enhanced …

Gadolinium (Gd3+) based dendrimers with precise and tunable nanoscopic sizes are
excellent candidates as magnetic resonance imaging (MRI) contrast agents. Control of …

Large macromolecular MRI contrast agents with albumin or dendrimer cores are useful for
imaging blood vessels. However, their prolonged retention is a major limitation for clinical …

The multivalent character of dendrimers has positioned these well-defined, highly branched
macromolecules at the forefront in the development of new contrast agents for biomedical …

Magnetic resonance imaging (MRI) is a powerful imaging modality that can provide an
assessment of function or molecular expression in tandem with anatomic detail. Over the last …

Dendrimers or dendritic polymers are a class of compounds with great potential for
nanomedical use. Some of their properties, including their rigidity, low polydispersity and the …