DNA lesions arise from a combination of physiological/metabolic sources and exogenous
environmental influences. When left unrepaired, these alterations accumulate in the cells …

Viruses are the causative agents of 10%–15% of human cancers worldwide. The most
common outcome for virus-induced reprogramming is genomic instability, including …

Simple Summary A large number of DNA damages occur per cell every day due to several
causes, including viral and bacterial infections. The majority of them are repaired, but in …

With between 10% and 15% of human cancers attributable to viral infection, there is great
interest, from both a scientific and clinical viewpoint, as to how these pathogens modulate …

About a fifth of all human cancers worldwide are caused by infectious agents. In 12% of
cancers, seven different viruses have been causally linked to human oncogenesis: Epstein …

Human oncogenic viruses are defined as necessary but not sufficient to initiate cancer.
Experimental evidence suggests that the oncogenic potential of a virus is effective in cells …

Simple Summary Carcinogens, causes of cancer, are usually invisible and therefore in vivo
carcinogenesis is difficult to detect. Tumor viruses, definitive carcinogens, are also usually …

Oncogenes encoded by human tumor viruses play integral roles in the viral conquest of the
host cell by subverting crucial and relatively non-redundant regulatory circuits that regulate …

The first experimental data suggesting that neoplasm development in animals might be
influenced by infectious agents were published in the early 1900s. However, conclusive …

The DNA damage response (DDR) has emerged as a critical tumour suppressor pathway
responding to cellular DNA replicative stress downstream of aberrant oncogene over …