Delivery systems of therapeutic nucleic acids for the treatment of acute lung injury/acute respiratory distress syndrome
C Zhuang, M Kang, M Lee - Journal of Controlled Release, 2023 - Elsevier
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a devastating
inflammatory lung disease with a high mortality rate. ALI/ARDS is induced by various …
inflammatory lung disease with a high mortality rate. ALI/ARDS is induced by various …
RNAi therapeutic strategies for acute respiratory distress syndrome
ML Jagrosse, DA Dean, A Rahman, BL Nilsson - Translational Research, 2019 - Elsevier
Acute respiratory distress syndrome (ARDS), replacing the clinical term acute lung injury,
involves serious pathophysiological lung changes that arise from a variety of pulmonary and …
involves serious pathophysiological lung changes that arise from a variety of pulmonary and …
[HTML][HTML] Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome
M Zoulikha, Q Xiao, GF Boafo, MA Sallam… - … Pharmaceutica Sinica B, 2022 - Elsevier
The use of small interfering RNAs (siRNAs) has been under investigation for the treatment of
several unmet medical needs, including acute lung injury/acute respiratory distress …
several unmet medical needs, including acute lung injury/acute respiratory distress …
Gene therapy for acute respiratory distress syndrome
J Liu, DA Dean - Frontiers in Physiology, 2022 - frontiersin.org
Acute respiratory distress syndrome (ARDS) is a devastating clinical syndrome that leads to
acute respiratory failure and accounts for over 70,000 deaths per year in the United States …
acute respiratory failure and accounts for over 70,000 deaths per year in the United States …
Gene therapy for ALI/ARDS
X Lin, DA Dean - Critical care clinics, 2011 - criticalcare.theclinics.com
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are lifethreatening
conditions of acute respiratory failure, which is induced by direct and indirect injury to the …
conditions of acute respiratory failure, which is induced by direct and indirect injury to the …
Progress in respiratory gene therapy
G McLachlan, EWFW Alton, AC Boyd… - Human gene …, 2022 - liebertpub.com
The prospect of gene therapy for inherited and acquired respiratory disease has energized
the research community since the 1980s, with cystic fibrosis, as a monogenic disorder …
the research community since the 1980s, with cystic fibrosis, as a monogenic disorder …
Targeted delivery of nucleic acid-based therapeutics to the pulmonary circulation
Targeted delivery of functional nucleic acids (genes and oligonucleotides) to pulmonary
endothelium may become a novel therapy for the treatment of various types of lung …
endothelium may become a novel therapy for the treatment of various types of lung …
Clinical review: gene-based therapies for ALI/ARDS: where are we now?
J Devaney, M Contreras, JG Laffey - Critical Care, 2011 - Springer
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) confer substantial
morbidity and mortality, and have no specific therapy. The accessibility of the distal lung …
morbidity and mortality, and have no specific therapy. The accessibility of the distal lung …
Effective lung-targeted RNAi in mice with peptide-based delivery of nucleic acid
We have previously developed efficient peptide-based nucleic acid delivery vectors PF14
and NF55, where we have shown that these vectors preferentially transfect lung tissue upon …
and NF55, where we have shown that these vectors preferentially transfect lung tissue upon …
Nucleic acid-based therapeutics for pulmonary diseases
J Chen, Y Tang, Y Liu, Y Dou - AAPS PharmSciTech, 2018 - Springer
Nucleic acid-based therapeutics present huge potential in the treatment of pulmonary
diseases ranging from lung cancer to asthma and chronic pulmonary diseases, which are …
diseases ranging from lung cancer to asthma and chronic pulmonary diseases, which are …