Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a devastating
inflammatory lung disease with a high mortality rate. ALI/ARDS is induced by various …

Acute respiratory distress syndrome (ARDS), replacing the clinical term acute lung injury,
involves serious pathophysiological lung changes that arise from a variety of pulmonary and …

Acute respiratory distress syndrome (ARDS), a rapid onset inflammatory lung disease with
no effective specific therapy, typically has pathogenic etiology termed pneumonia. In …

The use of small interfering RNAs (siRNAs) has been under investigation for the treatment of
several unmet medical needs, including acute lung injury/acute respiratory distress …

Acute respiratory distress syndrome (ARDS) is a devastating clinical syndrome that leads to
acute respiratory failure and accounts for over 70,000 deaths per year in the United States …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are lifethreatening
conditions of acute respiratory failure, which is induced by direct and indirect injury to the …

The prospect of gene therapy for inherited and acquired respiratory disease has energized
the research community since the 1980s, with cystic fibrosis, as a monogenic disorder …

Targeted delivery of functional nucleic acids (genes and oligonucleotides) to pulmonary
endothelium may become a novel therapy for the treatment of various types of lung …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) confer substantial
morbidity and mortality, and have no specific therapy. The accessibility of the distal lung …

We have previously developed efficient peptide-based nucleic acid delivery vectors PF14
and NF55, where we have shown that these vectors preferentially transfect lung tissue upon …