Background Diffusion tensor imaging measures of white matter (WM) microstructural
integrity appear to provide earlier indication of WM injury than WM hyperintensities; …

Objective We examined imaging surrogates of white matter microstructural abnormalities
which may precede white matter lesions (WML) and represent a relevant marker of …

Background Cardiovascular risk factors are associated with cognitive decline and dementia.
Magnetic resonance imaging provides sensitive measurement of brain morphology and …

Objective Coronary artery disease (CAD) is associated with an increased risk of cognitive
decline. Although cerebral white matter (WM) damage predicts cognitive function in CAD …

Abstract Background/Aims: This study investigated the relation of midlife blood pressure,
total cholesterol, body mass index (BMI), their changes over time, apolipoprotein E, and …

The goal of the study was to examine the differences in trajectories of change in the volume
of white matter hyperintensities (WMH) in healthy adults within a relatively short period. We …

White matter microstructure can be measured with diffusion tensor imaging (DTI). While
increasing age is a predictor of white matter (WM) microstructure changes, roles of other …

Hypertension, hyperlipidemia, and diabetes are increasingly prevalent with advancing age
and have been shown to cause white-matter (WM) injury that may contribute to dementia …

Cardiovascular health declines with age, increasing the risk of hypertension and elevated
heart rate in middle and old age. Here, we used multivariate techniques to investigate the …

Cerebral white matter damage is not only a commonly reported consequence of healthy
aging, but is also associated with cognitive decline and dementia. The aetiology of this …