The efficient delivery of antitumor agents to tumor sites faces numerous obstacles, such as
poor cellular uptake and slow intracellular drug release. In this regard, smart nanoparticles …

Physicochemical properties, including particle size, zeta potential, and drug release
behavior, affect targeting efficiency, cellular uptake, and antitumor effect of nanocarriers in a …

To bypass the biological barriers during the drug delivery process, it is desirable to develop
smart nanoparticles (NPs) with flexible physical and chemical properties. In this study, a …

Tumor microenvironment (TME) targeted strategy could control the drug release in tumor
cells more accurately and creates a new opportunity for enhanced site-specific targeted …

Advanced drug delivery systems often employ nanomaterials as carriers to deliver drugs to
desirable disease sites for enhanced efficacy. However, most systems have low drug …

The application of cytotoxic chemotherapeutics in cancer therapy has been largely restricted
by their lack of selectivity. Despite the existence of numerous targeted delivery systems, it is …

How to overcome the cell membrane barriers and achieve release payloads efficiently in the
cytoplasm have been major challenges for anticancer drug delivery and therapeutic effects …

Efficient intracellular drugs delivery and accumulation are the key determinant for
overcoming tumor multidrug resistance (MDR). To realize this purpose, dual-pH responsive …

Despite nanomedicine having shown great potential for reversing cancer cell resistance, the
suboptimal transport across multiple biological obstacles seriously impedes its reaching …

A multifunctional theranostic nanoplatform integrated with environmental responses has
been developed rapidly over the past few years as a novel treatment strategy for several …