An insufficient drug concentration at the target site and drug efflux resulting in poor efficacy
is recognized as important obstacles in tumor treatment. Herein, novel lipid nanoparticles …

In this study, novel smart pH-sensitive nanoparticles of PLA-mPEG 2000/TPGS 3350-PHis-
Folate for enhanced effect of chemotherapy are developed. Polyethylene glycol (PEG) is …

Enabling nanocarriers to complete the sophisticated journey from the initial injection site to
the targeted tumor cells and achieve “spatiotemporally pinpointed” drug release …

To achieve higher therapeutic efficiency with catabatic side effects, desirable nanocarriers
should be designed to retain the loaded drug tightly during the systemic circulation, but …

Modification with polyethylene glycol (PEG) is currently considered an important strategy for
anti-cancer drug delivery, because PEGylated-nanoparticles would be effectively delivered …

Tamoxifen (Tam) has a broad spectrum of anticancer activity, but is limited in clinical
application. The aim of this study was to explore the smart pH-responsive drug delivery …

Hierarchical responsive nanocarriers have received much attention for targeted delivery of
chemotherapeutics. In this study, we designed pH and redox dual-stage responsive …

Current chemotherapeutic strategies against various intractable cancers are futile due to
inefficient delivery, poor bioavailability, and inadequate accumulation of anticancer drugs in …

Developing a smart drug delivery system with enhanced tumor retention at the tumor site,
and rapid intracellular drug release promises to improve the therapeutic index and mitigate …

Cancer stem cells (CSCs) have the ability to transform into bulk cancer cells, to promote
tumor growth and establish tumor metastasis. To effectively inhibit tumor growth and prevent …