Recent progress in stimuli-responsive intelligent nano scale drug delivery systems: a special focus towards pH-sensitive systems

V Sethuraman, K Janakiraman… - Current Drug …, 2021 - ingentaconnect.com
Stimuli-responsive nanocarriers are gaining much attention due to their versatile
multifunctional activities, including disease diagnosis and treatment. Recently, clinical …

Drug delivery of pH-Sensitive nanoparticles into the liver cancer cells

M Saadat, F Mostafaei, S Mahdinloo, M Abdi… - Journal of Drug Delivery …, 2021 - Elsevier
Nanotechnology is a developing strategy to overcome the disadvantages of traditional liver
cancer chemotherapy. For this purpose, different kinds of nanoparticles (NPs) regarding …

A pH‐responsive nanoparticle delivery system containing dihydralazine and doxorubicin‐based prodrug for enhancing antitumor efficacy

L Zhang, J Huang, D Buratto, P Han, Z Yang… - Aggregate, 2024 - Wiley Online Library
The efficacy of nanoparticle (NP)‐based drug delivery technology is hampered by aberrant
tumor stromal microenvironments (TSMs) that hinder NP transportation. Therefore, the …

pH triggered re-assembly of nanosphere to nanofiber: The role of peptide conformational change for enhanced cancer therapy

P Liang, J Zheng, S Dai, J Wang, Z Zhang… - Journal of Controlled …, 2017 - Elsevier
Abstract pH-triggered conformational change and subsequent re-assembly of
nanostructures provide a new strategy in nanomedicine for controlled drug release and …

Protein stabilized polymeric nanoparticles inspired relay drug delivery for tackling post-chemotherapeutic metastasis

H Cheng, Z Jiang, C Sun, Z Wang, G Han… - Chemical Engineering …, 2022 - Elsevier
The pro-metastatic potential of chemotherapy limits its therapeutic benefits against invasive
cancer. Herein, a protein stabilized polymeric nanoparticle inspired relay drug delivery …

Tumor pH e-triggered charge-reversal and redox-responsive nanoparticles for docetaxel delivery in hepatocellular carcinoma treatment

F Chen, J Zhang, L Wang, Y Wang, M Chen - Nanoscale, 2015 - pubs.rsc.org
The insufficient cellular uptake of nanocarriers and their slow drug release have become
major obstacles for achieving satisfactory anticancer outcomes in nano-medicine therapy …

pH/redox dual stimuli-responsive sheddable nanodaisies for efficient intracellular tumour-triggered drug delivery

JV John, S Uthaman, R Augustine, H Chen… - Journal of Materials …, 2017 - pubs.rsc.org
A series of dual stimuli-responsive poly (L-histidine) nSS-polyurethane-SS-poly (L-histidine)
n [p (His) n-SS-PU-SS-p (His) n; n= 25, 35, 50, and 75] triblock copolymers that bear two pH …

pH-triggered intracellular release from actively targeting polymer micelles

X Guo, C Shi, J Wang, S Di, S Zhou - Biomaterials, 2013 - Elsevier
Chemotherapy is widely applied to treat cancer patients but its application is limited due to
the systemic toxicity and low efficacy. Nanocarrier system, which is capable of delivering …

Efficient fabrication of reversible pH-induced carboxymethyl chitosan nanoparticles for antitumor drug delivery under weakly acidic microenvironment

T Li, J Yang, R Liu, Y Yi, M Huang, Y Wu, H Tu… - International journal of …, 2019 - Elsevier
Searching for the carrier systems for drug controlled release under weakly acidic condition
related to tumor environment has attracted a tremendous level of attention. In this study …

Endogenous stimuli-responsive nanoparticles for cancer therapy: from bench to bedside

F Xie, M Wang, Q Chen, T Chi, S Zhu, P Wei… - Pharmacological …, 2022 - Elsevier
Cancer is complicated to treat because of its high propensity for recurrence and metastasis,
and various side effects of conventional cancer treatments. With the development of …