Molecular mechanisms underlying chemopreventive potential of butein: Current trends and future perspectives

HS Tuli, R Joshi, D Aggarwal, G Kaur, J Kaur… - Chemico-Biological …, 2021 - Elsevier
Despite extensive efforts, cancer is still often considered as an incurable disease and
initiation of novel drug development programs is crucial to improve the prognosis and …

Potential of butein, a tetrahydroxychalcone to obliterate cancer

G Padmavathi, SR Rathnakaram, J Monisha… - Phytomedicine, 2015 - Elsevier
Background Despite the major advances made in the field of cancer biology, it still remains
one of the most fatal diseases in the world. It is now well established that natural products …

Molecular chemotherapeutic potential of butein: A concise review

RGPT Jayasooriya, IMN Molagoda, C Park… - Food and chemical …, 2018 - Elsevier
Butein is a biologically active flavonoid isolated from the bark of Rhus verniciflua Stokes,
which is known to have therapeutic potential against various cancers. Notably, butein …

Butein: From ancient traditional remedy to modern nutraceutical

RB Semwal, DK Semwal, S Combrinck, A Viljoen - Phytochemistry Letters, 2015 - Elsevier
Abstract Butein (2′, 3, 4, 4′-tetrahydroxychalcone), a simple chalcone derivative, occurs in
many unrelated genera including Butea Dahlia, Coreopsis and Searsia. It is a reputed food …

Butein and its role in chronic diseases

Z Song, MK Shanmugam, H Yu, G Sethi - Anti-inflammatory Nutraceuticals …, 2016 - Springer
Natural compounds isolated from various plant sources have been used for therapeutic
purpose for centuries. These compounds have been routinely used for the management of …

Butein suppresses cervical cancer growth through the PI3K/AKT/mTOR pathway

X Bai, Y Ma, G Zhang - Oncology reports, 2015 - spandidos-publications.com
Cervical cancer is the second most common women carcinoma worldwide and the fourth
leading cause of cancer‑associated mortality in women. Butein, a bioactive flavonoid …

Butein induces apoptotic cell death of human cervical cancer cells

PY Yang, DN Hu, YH Kao, I Lin… - Oncology …, 2018 - spandidos-publications.com
Butein is a chalcone, a flavonoid that is widely biosynthesized in plants. Butein has been
identified to possess varied pharmacological activity and is extractable from traditional …

Butein shows cytotoxic effects and induces apoptosis in human ovarian cancer cells

PY Yang, DN Hu, IC Lin, FS Liu - The American journal of Chinese …, 2015 - World Scientific
Butein is a polyphenol, one of the compounds of chalcones, which are flavonoids that are
widely biosynthesized in plants, and exhibits different pharmacological activities. Plants …

[HTML][HTML] PERK/eIF-2α/CHOP pathway dependent ROS generation mediates butein-induced non-small-cell lung cancer apoptosis and G2/M phase arrest

S Di, C Fan, Z Ma, M Li, K Guo, D Han, X Li… - … Journal of Biological …, 2019 - ncbi.nlm.nih.gov
Butein, a member of the chalcone family, is a potent anticarcinogen against multiple
cancers, but its specific anti-NSCLC mechanism remains unknown. The present study …

Molecular mechanisms of antiproliferative effects of natural chalcones

R Michalkova, L Mirossay, M Gazdova, M Kello… - Cancers, 2021 - mdpi.com
Simple Summary Despite the important progress in cancer treatment in the past decades,
the mortality rates in some types of cancer have not significantly decreased. Therefore, the …