Tanshinone IIA targeting cell signaling pathways: A plausible paradigm for cancer therapy

SSM Alam, A Samanta, F Uddin, S Ali… - Pharmacological Reports, 2023 - Springer
Natural compounds originating from plants offer a wide range of pharmacological potential
and have traditionally been used to treat a wide range of diseases including cancer …

Comprehensive review on betulin as a potent anticancer agent

SK Król, M Kiełbus, A Rivero-Müller… - BioMed research …, 2015 - Wiley Online Library
Numerous plant‐derived substances, and their derivatives, are effective antitumour and
chemopreventive agents. Yet, there are also a plethora of tumour types that do not respond …

[HTML][HTML] The fascinating effects of baicalein on cancer: a review

H Liu, Y Dong, Y Gao, Z Du, Y Wang, P Cheng… - International journal of …, 2016 - mdpi.com
Cancer is one of the leading causes of death worldwide and a major global health problem.
In recent decades, the rates of both mortality and morbidity of cancer have rapidly increased …

Brassinin enhances the anticancer actions of paclitaxel by targeting multiple signaling pathways in colorectal cancer cells

MH Yang, SH Baek, IJ Ha, JY Um… - Phytotherapy …, 2021 - Wiley Online Library
Brassinin (BSN), a precursor of phytoalexins, extracted from Chinese cabbage has been
reported to act as a promising anti‐neoplastic agent. However, the effects of BSN on colon …

Advances in molecular signaling mechanisms of β-phenethyl isothiocyanate antitumor effects

CZ Qin, X Zhang, LX Wu, CJ Wen, L Hu… - Journal of agricultural …, 2015 - ACS Publications
β-Phenethyl isothiocyanate (PEITC) is an important phytochemical from cruciferous
vegetables and is being evaluated for chemotherapeutic activity in early phase clinical trials …

Anti-tumour effects of beta-sitosterol are mediated by AMPK/PTEN/HSP90 axis in AGS human gastric adenocarcinoma cells and xenograft mouse models

EJ Shin, HK Choi, MJ Sung, JH Park, MY Chung… - Biochemical …, 2018 - Elsevier
We investigated the anti-cancer effects of beta-sitosterol (BS), a plant-derived sterol in AGS
human gastric adenocarcinoma cells and xenograft mouse models. BS significantly reduced …

Chalcone arrests cell cycle progression and induces apoptosis through induction of mitochondrial pathway and inhibition of nuclear factor kappa B signalling in …

KH Shen, JK Chang, YL Hsu… - Basic & clinical …, 2007 - Wiley Online Library
Chalcones (1, 3‐diphenyl‐2‐propenone) are cancer preventive food components found in a
human diet rich in fruits and vegetables. In this study, we first report the chemopreventive …

[HTML][HTML] Apigenin role as cell-signaling pathways modulator: implications in cancer prevention and treatment

Z Javed, H Sadia, MJ Iqbal, S Shamas, K Malik… - Cancer Cell …, 2021 - Springer
Cancer is a complex disease orchestrated by various extrinsic and intrinsic pathways. In
recent years, there has been a keen interest towards the development of natural extracts …

Effects of butein on human osteosarcoma cell proliferation, apoptosis, and autophagy through oxidative stress

P Zhang, J Zhang, H Quan, P Chen… - Human & …, 2022 - journals.sagepub.com
Purpose Osteosarcoma (OS) is a primary malignant bone tumor, and the cure rate has
stagnated in the past three decades. Butein, a plant polyphenol extracted from many herbs …

Phyto‐therapeutic potential of Withania somnifera: Molecular mechanism and health implications

N Yadav, S Tripathi, NS Sangwan - Phytotherapy Research, 2024 - Wiley Online Library
Withania somnifera, the plant named Indian ginseng, Ashwagandha, or winter cherry, has
been used since ancient times to cure various health ailments. Withania somnifera is rich in …