Copper is a metal ion that is required as a micronutrient for growth and proliferation.
However, copper accumulation generates toxicity by multiple mechanisms, potentially …

Fungal cells colonize and proliferate in distinct niches, from soil and plants to diverse tissues
in human hosts. Consequently, fungi are challenged with the goal of obtaining nutrients …

Copper is an essential micronutrient for the opportunistic human pathogen, Aspergillus
fumigatus. Maintaining copper homeostasis is critical for survival and pathogenesis. Copper …

The survival of pathogenic fungi in the host after adhesion and invasion depends on their
ability to obtain nutrients, including the transition metal copper, which performs several …

Aspergillus fumigatus can cause severe invasive aspergillosis in immunocompromised
individuals. Copper, an essential but potentially toxic trace element for A. fumigatus, plays a …

Fungal pathogens have evolved sophisticated machinery to precisely balance the fine line
between acquiring essential metals and defending against metal toxicity. Iron and copper …

Copper homeostasis has been extensively studied in mammals, bacteria, and yeast, but it
has not been well-documented in filamentous fungi. In this report, we investigated the basis …

Metals are essential for life, and they play a central role in the struggle between infecting
microbes and their hosts. In fact, an important aspect of microbial pathogenesis is the …

Highlights•Aspergillus fumigatus requires metal ion uptake in the host environment.•Metal-
homeostatic circuits are complex and multifactorial.•Imbalances in metal homeostasis affect …

The Fenton-chemistry-generating properties of copper ions are considered a potent
phagolysosome defense against pathogenic microbes, yet our understanding of underlying …