Insights from the HuR-interacting transcriptome: ncRNAs, ubiquitin pathways, and patterns of secondary structure dependent RNA interactions
G St Laurent, D Shtokalo, M Heydarian… - Molecular genetics and …, 2012 - Springer
The HuR protein regulates the expression of thousands of cellular transcripts by modulating
mRNA splicing, trafficking, translation, and stability. Although it serves as a model of RNA …
mRNA splicing, trafficking, translation, and stability. Although it serves as a model of RNA …
Functional interplay between RNA-binding protein HuR and microRNAs
S Srikantan, K Tominaga… - Current Protein and …, 2012 - ingentaconnect.com
The mammalian RNA-binding protein (RBP) HuR associates with numerous mRNAs
encoding proteins with roles in cell division, cell survival, immune response, and …
encoding proteins with roles in cell division, cell survival, immune response, and …
[HTML][HTML] Global analysis of HuR-regulated gene expression in colon cancer systems of reducing complexity
IL De Silanes, J Fan, CJ Galbán, RG Spencer… - Gene …, 2004 - ncbi.nlm.nih.gov
HuR, a protein that binds to target mRNAs and can enhance their stability and translation, is
increasingly recognized as a pivotal regulator of gene expression during cell division and …
increasingly recognized as a pivotal regulator of gene expression during cell division and …
Identification of small-molecule inhibitors of the HuR/RNA interaction using a fluorescence polarization screening assay followed by NMR validation
The human antigen R (HuR) stabilizes many mRNAs of proto-oncogene, transcription
factors, cytokines and growth factors by recognizing AU-rich elements (AREs) presented in …
factors, cytokines and growth factors by recognizing AU-rich elements (AREs) presented in …
Posttranslational control of HuR function
I Grammatikakis, K Abdelmohsen… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
The RNA‐binding protein HuR (human antigen R) associates with numerous transcripts,
coding and noncoding, and controls their splicing, localization, stability, and translation …
coding and noncoding, and controls their splicing, localization, stability, and translation …
Identification of a target RNA motif for RNA-binding protein HuR
IL De Silanes, M Zhan, A Lal… - Proceedings of the …, 2004 - National Acad Sciences
HuR, a protein that binds to specific mRNA subsets, is increasingly recognized as a pivotal
posttranscriptional regulator of gene expression. Here, HuR was immunoprecipitated under …
posttranscriptional regulator of gene expression. Here, HuR was immunoprecipitated under …
HuR: post-transcriptional paths to malignancy
The RNA-binding protein HuR regulates the stability and translation of target mRNAs. While
no HuR mutations have been found in cancer, a link between HuR and malignant …
no HuR mutations have been found in cancer, a link between HuR and malignant …
The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets
RM Scheiba, AI de Opakua, A Díaz-Quintana… - RNA biology, 2014 - Taylor & Francis
Human antigen R (HuR) is a 32 kDa protein with 3 RNA Recognition Motifs (RRMs), which
bind to Adenylate and uridylate Rich Elements (AREs) of mRNAs. Whereas the N-terminal …
bind to Adenylate and uridylate Rich Elements (AREs) of mRNAs. Whereas the N-terminal …
[HTML][HTML] Adaptive and maladaptive expression of the mRNA regulatory protein HuR
S Govindaraju, BS Lee - World journal of biological chemistry, 2013 - ncbi.nlm.nih.gov
The RNA-binding proteins involved in regulation of mRNA post-transcriptional processing
and translation control the fates of thousands of mRNA transcripts and basic cellular …
and translation control the fates of thousands of mRNA transcripts and basic cellular …
Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability
RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying
these global interactions remain poorly understood. We elucidated regulatory mechanisms …
these global interactions remain poorly understood. We elucidated regulatory mechanisms …