The pig is an omnivorous, monogastric species with many advantages to serve as an animal
model for human diseases. There are very high similarities to humans in anatomy and …

The limited availability of deceased human organs and cells for the purposes of clinical
transplantation remains critical worldwide. Despite the increasing utilization of 'high …

In most animals, the mucosal immune system effectively controls expression of active
immune responses to pathogen and tolerance to harmless antigens. Our understanding of …

Over the last few years, we have seen an increasing interest and demand for pigs in
biomedical research. Domestic pigs (Sus scrofa domesticus) are closely related to humans …

If the immunological problems could be overcome, the ideal animal organ donor for man
would be an animal that is readily available throughout the world in large numbers and …

In this article the anatomical structure of the porcine immune organs is described. The focus
is on their particularities that are related to the use of pigs as an animal model. Key issues of …

Previous experiments displayed consistent individual behavioural differences in pigs. Some
showed a more active behavioural response (aggressive and resistant; so-called AR pigs) …

There is a critical shortage in the number of deceased human organs that become available
for the purposes of clinical transplantation. This problem might be resolved by the …

The biology of cells of the mononuclear phagocyte system has been studied extensively in
the mouse. Studies of the pig as an experimental model have commonly been consigned to …

European-wide directives are in place to establish a sustainable production of pigs without
using production enhancers and chemotherapeutics. Thus, an economically-viable pig …