It is well established that pig gut microbiota plays a critical role in maintaining metabolic
homeostasis as well as in a myriad of physiological, neurological and immunological …

Most animals are colonised by at least as many microbial cells as somatic cells, potentially
comprising at least 100 times more genes within just the gut microbiota than the host itself. It …

To improve the welfare of experimental animals, investigators seek to respect the 3R
principle (Replacement, Reduction, and Refinement). Even when large animal studies are …

Xenotransplantation using pig organs could solve the significant increasing shortage of
donor organs for allotransplantation. In the last two decades, major progress has been made …

Using monoclonal antibodies in immunohistochemistry, the distribution of the cells with the
following surface antigens was studied in samples of proximal and distal small intestine of …

The intestinal epithelial cells (IEC) play an important role in the immune system of swine,
protecting against infectious and non-infectious environmental insults. The IEC participate in …

Gut-associated lymphoid tissues (GALTs) comprise key intestinal immune inductive sites,
including the Peyer's patches of the small intestine and different types of isolated lymphoid …

▪ Abstract The increasing shortage of human cadaveric organs for purposes of
transplantation has become the critical limiting factor in the number of transplants performed …

The intestinal microflora lives in intimate contact with its surrounding intestinal wall and the
bacteria can exert beneficial or deleterious effects on the host, depending on whether they …

The shortage of donor organs is a major barrier to clinical organ transplantation. Although
xenotransplantation is considered one of the alternatives to human organ transplantation …