The etiopathogenesis of testicular failure remains unknown in about half of the cases and is
referred to as “idiopathic infertility”.“Idiopathic” testicular failure is of probable genetic origin …

Male infertility is a multifactorial complex disease with highly heterogeneous phenotypic
representation and in at least 15% of cases, this condition is related to known genetic …

Many genetic polymorphisms have been studied extensively to elucidate their role in the
pathophysiology of male infertility. This article presents a review of the literature following a …

Despite the identification of an increasing number of candidate genes involved in
spermatogenesis, the armamentarium of diagnostic genetic tests in male infertility remains …

Genetic causes can be directly responsible for various clinical conditions of male infertility
and spermatogenic impairment. With the increased use of assisted reproduction …

Genetic causes account for 10–15% of severe male infertility, including chromosomal
aberrations and single gene mutations. Natural selection prevents the transmission of …

Male infertility is an extraordinarily common problem affecting 1 in 25 men. Despite active
research, the underlying causal factors remain unknown in a large percentage (40%) of …

Male infertility represents one of the clearest examples of a complex disease with a
substantial genetic basis. Numerous male mouse models, mutation screening and …

Infertility is a common condition estimated to affect 10–15% of couples. The clinical causes
are attributed in equal parts to the male and female partners. Diagnosing male infertility …

Infertility is one of the most serious social problems facing advanced nations. In general,
approximate half of all cases of infertility are caused by factors related to the male partner …