Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177® (Dapansutrile) in a Mouse Model of Severe …
J Aliaga, A Bonaventura, E Mezzaroma, Y Dhakal… - Molecules, 2021 - mdpi.com
Interleukin-1β (IL-1β), a product of the NLRP3 inflammasome, modulates cardiac contractility
and diastolic function. We proposed that OLT1177®(dapansutrile), a novel NLRP3 inhibitor …
and diastolic function. We proposed that OLT1177®(dapansutrile), a novel NLRP3 inhibitor …
The NLRP3 inflammasome inhibitor, OLT1177 (dapansutrile), reduces infarct size and preserves contractile function after ischemia reperfusion injury in the mouse
Background: Activation of the NLRP3 inflammasome is a primary driver of sterile
inflammation in response to myocardial ischemia reperfusion. Pharmacologic inhibitors of …
inflammation in response to myocardial ischemia reperfusion. Pharmacologic inhibitors of …
Pharmacologic inhibition of the NLRP3 inflammasome preserves cardiac function after ischemic and nonischemic injury in the mouse
Background: Sterile inflammation resulting from myocardial injury activates the NLRP3
inflammasome and amplifies the inflammatory response mediating further damage …
inflammasome and amplifies the inflammatory response mediating further damage …
The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction
GPJ Van Hout, L Bosch, GHJM Ellenbroek… - European heart …, 2017 - academic.oup.com
Aims Myocardial infarction (MI) triggers an intense inflammatory response that is associated
with infarct expansion and is detrimental for cardiac function. Interleukin (IL)-1β and IL-18 …
with infarct expansion and is detrimental for cardiac function. Interleukin (IL)-1β and IL-18 …
The selective NLRP3-inflammasome inhibitor MCC950 reduces myocardial fibrosis and improves cardiac remodeling in a mouse model of myocardial infarction
R Gao, H Shi, S Chang, Y Gao, X Li, C Lv… - International …, 2019 - Elsevier
Abstract Background/Aims. Early inflammatory responses after myocardial infarction (MI) are
likely to increase myocardial fibrosis and subsequent cardiac remodeling. MCC950, a …
likely to increase myocardial fibrosis and subsequent cardiac remodeling. MCC950, a …
NLRP3-inflammasome inhibition with IZD334 does not reduce cardiac damage in a pig model of myocardial infarction
MJM Silvis, EJ Demkes, L Timmers, F Arslan… - Biomedicines, 2022 - mdpi.com
NLRP3-inflammasome-mediated signaling is thought to significantly contribute to the extent
of myocardial damage after myocardial infarction (MI). The purpose of this study was to …
of myocardial damage after myocardial infarction (MI). The purpose of this study was to …
Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia–reperfusion in the mouse
Background Successful reperfusion is the most effective strategy to reduce ischemic injury in
acute myocardial infarction (AMI). Ischemic injury, however, also triggers a secondary …
acute myocardial infarction (AMI). Ischemic injury, however, also triggers a secondary …
Role of NLRP3 inflammasome in cardiac inflammation and remodeling after myocardial infarction
M Takahashi - Biological and Pharmaceutical Bulletin, 2019 - jstage.jst.go.jp
An accumulating body of evidence indicates that inflammation plays a crucial role in the
pathophysiology of myocardial infarction (MI). Nucleotide-binding oligomerization domain …
pathophysiology of myocardial infarction (MI). Nucleotide-binding oligomerization domain …
Inhibiting NLRP3 inflammasome activity in acute myocardial infarction: a review of pharmacologic agents and clinical outcomes
LF Buckley, P Libby - Journal of Cardiovascular Pharmacology, 2019 - journals.lww.com
The NLRP3 inflammasome is an intracellular, multimeric protein complex that initiates a
potent inflammatory response to danger signals. After acute myocardial infarction, NLRP3 …
potent inflammatory response to danger signals. After acute myocardial infarction, NLRP3 …
The selective NLRP3-inflammasome inhibitor MCC950 mitigates post-resuscitation myocardial dysfunction and improves survival in a rat model of cardiac arrest and …
G Zheng, F He, J Xu, J Hu, W Ge, X Ji, C Wang… - … Drugs and Therapy, 2023 - Springer
Purpose To investigate the effects of the selective NLRP3 inflammasome inhibitor MCC950
on post-resuscitation myocardial function and survival in a rat model of cardiopulmonary …
on post-resuscitation myocardial function and survival in a rat model of cardiopulmonary …