Mitochondria are essential in most eukaryotes and are involved in numerous biological
functions including ATP production, cofactor biosyntheses, apoptosis, lipid synthesis, and …

The biogenesis of iron–sulfur (Fe/S) proteins in eukaryotes is a multistage,
multicompartment process that is essential for a broad range of cellular functions, including …

Mitochondria play a key role in iron metabolism in that they synthesize heme, assemble iron–
sulfur (Fe/S) proteins, and participate in cellular iron regulation. Here, we review the latter …

Iron–sulfur (Fe/S) clusters are important cofactors of numerous proteins involved in electron
transfer, metabolic and regulatory processes. In eukaryotic cells, known Fe/S proteins are …

Iron–sulfur (Fe/S) clusters belong to the most ancient protein cofactors in life, and fulfill
functions in electron transport, enzyme catalysis, homeostatic regulation, and sulfur …

Protein cofactors often are the business ends of proteins, and are either synthesized inside
cells or are taken up from the nutrition. A cofactor that strictly needs to be synthesized by …

Abstract Iron-sulfur (Fe/S) clusters require a complex set of proteins to become assembled
and incorporated into apoproteins in a living cell. Researchers have described three distinct …

In eukaryotes, mitochondria execute a central task in the assembly of cellular iron-sulfur
(Fe/S) proteins. The organelles synthesize their own set of Fe/S proteins, and they initiate …

Iron–sulfur (Fe–S) clusters (ISCs) are versatile, ancient co-factors of proteins that are
involved in electron transport, enzyme catalysis and regulation of gene expression. The …

Work during the past 14 years has shown that mitochondria are the primary site for the
biosynthesis of iron–sulfur (Fe/S) clusters. In fact, it is this process that renders mitochondria …