[HTML][HTML] Utility of gene methylation analysis, cytological examination, and HPV-16/18 genotyping in triage of high-risk human papilloma virus-positive women

Y Tian, NYY Wu, YL Liou, CT Yeh, L Cao, YN Kang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract In 2015, the American Society for Colposcopy and Cervical Pathology and the
Society of Gynecologic Oncology issued interim guidance for the use of a human …

Validation of a DNA methylation HPV triage classifier in a screening sample

AT Lorincz, AR Brentnall… - … journal of cancer, 2016 - Wiley Online Library
High‐risk human papillomavirus (hrHPV) DNA tests have excellent sensitivity for detection of
cervical intraepithelial neoplasia 2 or higher (CIN2+). A drawback of hrHPV screening …

Methylation estimates the risk of precancer in HPV-infected women with discrepant results between cytology and HPV16/18 genotyping

R Hernández-López, AT Lorincz, L Torres-Ibarra… - Clinical …, 2019 - Springer
Background Vigilant management of women with high-risk human papillomavirus (hrHPV) is
necessary in cancer screening programs. To this end, we evaluated the performance of S5 …

Evaluation of a validated methylation triage signature for human papillomavirus positive women in the HPV FOCAL cervical cancer screening trial

DA Cook, M Krajden, AR Brentnall… - … Journal of Cancer, 2019 - Wiley Online Library
Human papillomavirus (HPV)‐based cervical cancer screening requires triage of HPV
positive women to identify those at risk of cervical intraepithelial neoplasia grade 2 (CIN2) or …

Risk stratification of HPV 16 DNA methylation combined with E6 oncoprotein in cervical cancer screening: a 10-year prospective cohort study

L Dong, L Zhang, SY Hu, RM Feng, XL Zhao… - Clinical …, 2020 - Springer
Background How to best triage human papillomavirus (HPV) positive women remains
controversial in an era of HPV primary screening of cervical cancer. Here, we assessed the …

Human papillomavirus DNA methylation as a biomarker for cervical precancer: consistency across 12 genotypes and potential impact on management of HPV-positive …

MA Clarke, A Gradissimo, M Schiffman, J Lam… - Clinical Cancer …, 2018 - AACR
Abstract Purpose: Human papillomavirus (HPV) DNA methylation testing is a promising
triage option for women testing HPV positive during cervical cancer screening. However, the …

DNA methylation markers as a triage test for identification of cervical lesions in a high risk human papillomavirus positive screening cohort

RW van Leeuwen, A Oštrbenk, M Poljak… - … Journal of Cancer, 2019 - Wiley Online Library
Objective triage strategies are required to prevent unnecessary referrals for colposcopy in
population‐based screening programs using primary high‐risk human papillomavirus …

A promising DNA methylation signature for the triage of high-risk human papillomavirus DNA-positive women

A Hansel, D Steinbach, C Greinke, M Schmitz, J Eiselt… - PloS one, 2014 - journals.plos.org
High-risk human papillomavirus (hrHPV)-DNA testing is frequently performed parallel to
cytology for the detection of high-grade dysplasia and cervical cancer particularly in women …

HPV33 DNA methylation measurement improves cervical pre-cancer risk estimation of an HPV16, HPV18, HPV31 and\textit {EPB41L3} methylation classifier

AR Brentnall, N Vasiljevic… - Cancer …, 2015 - content.iospress.com
BACKGROUND: Persistent infection% by with high risk human papillomavirus (hrHPV) types
causes cervical cancer but most women who test positive are at very low risk of neoplasia …

Triage of hrHPV-positive women: comparison of two commercial methylation-specific PCR assays

C Dippmann, M Schmitz, K Wunsch, S Schütze… - Clinical …, 2020 - Springer
Aim High-risk human papillomavirus (hrHPV)-based screening is becoming increasingly
important, either by supplementing or replacing the traditional cytology-based cervical Pap …