Melatonin protects against chronic stress-induced oxidative meiotic defects in mice MII oocytes by regulating SIRT1

Y Guo, J Sun, S Bu, B Li, Q Zhang, Q Wang, D Lai - Cell Cycle, 2020 - Taylor & Francis
Chronic stress which is common in the current society can be harmful to female reproduction
and is associated with oocyte defects. However, the underlying mechanisms remain largely …

Melatonin attenuates postovulatory oocyte dysfunction by regulating SIRT1 expression

Q Yang, S Dai, X Luo, J Zhu, F Li, J Liu, G Yao… - …, 2018 - rep.bioscientifica.com
The quality of postovulatory metaphase II oocytes undergoes a time-dependent deterioration
as a result of the aging process. Melatonin is considered to be an anti-aging agent …

[HTML][HTML] Insufficiency of melatonin in follicular fluid is a reversible cause for advanced maternal age-related aneuploidy in oocytes

M Zhang, Y Lu, Y Chen, Y Zhang, B Xiong - Redox biology, 2020 - Elsevier
Age-related decline in female fertility is a common feature that occurs in the fourth decade of
women as a result of a reduction in both oocyte quality and quantity [1]. However, strategies …

[HTML][HTML] Melatonin ameliorates the advanced maternal age-associated meiotic defects in oocytes through the SIRT2-dependent H4K16 deacetylation pathway

C Li, X He, Z Huang, L Han, X Wu, L Li, Y Xin… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
It has been widely reported that advanced maternal age impairs oocyte quality. To date,
various molecules have been discovered to be involved in this process. However …

Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice

C Song, W Peng, S Yin, J Zhao, B Fu, J Zhang, T Mao… - Scientific reports, 2016 - nature.com
Increasing evidence shows that melatonin protected against age-related mitochondrial
oxidative damage. However, the protective effects of melatonin against ovarian aging has …

Melatonin restores the declining maturation quality and early embryonic development of oocytes in aged mice

J Qu, H Hu, H Niu, X Sun, Y Li - Theriogenology, 2023 - Elsevier
With increase in women's age, the reproductive capability of female mammals decreases
dramatically caused by age-related oxidative stress, coinciding with the decline in the …

Melatonin protects against maternal obesity‐associated oxidative stress and meiotic defects in oocytes via the SIRT 3‐SOD 2‐dependent pathway

L Han, H Wang, L Li, X Li, J Ge… - Journal of pineal …, 2017 - Wiley Online Library
Maternal obesity in humans is associated with poor outcomes across the reproductive
spectrum. Emerging evidence indicates that these defects are likely attributed to factors …

Melatonin promotes parthenogenetic development of vitrified-warmed mouse MII oocytes, potentially by reducing oxidative stress through SIRT1

T Lv, B Cao, J Qin, Y Wei, B Pan, J Ye, G Zhou - Theriogenology, 2023 - Elsevier
Previous studies have demonstrated that melatonin could ameliorate oxidative stress during
the cryopreservation of mouse MII oocytes and their in vitro culture after parthenogenetic …

Melatonin protects mouse oocytes from DNA damage by enhancing nonhomologous end‐joining repair

J Leem, GY Bai, JS Kim, JS Oh - Journal of Pineal Research, 2019 - Wiley Online Library
Mammalian oocytes remain arrested at the first prophase of meiosis in ovarian follicles for
an extended period. During this protracted arrest, oocytes are remarkably susceptible to the …

SIRT1 signalling protects mouse oocytes against oxidative stress and is deregulated during aging

G Di Emidio, S Falone, M Vitti… - Human …, 2014 - academic.oup.com
Abstract STUDY QUESTION Is SIRT1 involved in the oxidative stress (OS) response in
mouse oocytes? SUMMARY ANSWER SIRT1 plays a pivotal role in the adaptive response …