Pharmacokinetic changes are often seen in patients with severe infections. Administration
by continuous infusion has been suggested to optimize antibiotic exposure and …

Sufficient antibiotic dosing in septic patients is essential for reducing mortality. Piperacillin-
tazobactam is often used for empirical treatment, but due to the pharmacokinetic (PK) …

Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-
lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models …

Piperacillin plasma concentrations are known to vary between critically ill patients. However,
there are no comprehensive data on the variability of antibiotic concentrations within the …

Optimal dosing of β-lactam antibiotics in critically ill patients is a challenge given the
unpredictable pharmacokinetic profile of this patient population. Several studies have shown …

The objectives of this study were (i) to compare the plasma concentration–time profiles for
first-dose and steady-state piperacillin administered by intermittent or continuous dosing to …

Study Objective To evaluate the pharmacokinetic and pharmacodynamic profiles of
piperacillin‐tazobactam administered as a 4‐hour infusion in critically ill patients undergoing …

Antibiotic dosing in septic shock patients poses a challenge for clinicians due to the
pharmacokinetic (PK) variability seen in this patient population. Piperacillin-tazobactam is …

Abstract Background and Objectives Although dose optimization studies have been
performed for piperacillin and tazobactam separately, a combined integral analysis is not yet …

The objective of this study was to evaluate the steady-state pharmacokinetics and
pharmacodynamics of piperacillin/tazobactam, administered by prolonged infusion, in …