Retroviral vectors derived from murine leukemia virus (MLV) are used in somatic gene
therapy applications eg for genetic modification of hematopoietic stem cells. Recently, we …

Retroviral vectors derived from murine leukemia virus (MLV) are amongst the most
frequently utilized vectors in gene therapy approaches such as the genetic modification of …

Several patients with severe combined immunodeficiency-X1 disease and adenosine
deaminase deficiency have been cured by retroviral-mediated gene therapy. Despite the …

Retroviral vectors are powerful tools for gene transfer that are useful in the context of
experimental as well as clinical applications. Defective recombinant retroviruses allow for …

Lentiviral vectors are increasingly utilized in cell and gene therapy applications because
they efficiently transduce target cells such as hematopoietic stem cells and T cells. Large …

Background For many inherited and acquired diseases of the blood system, gene transfer
into hematopoietic cells is a promising strategy to alleviate disease‐related symptoms or …

Hematopoietic cells, in particular hematopoietic stem cells, are important targets for the
development of gene therapy for hematological and other disorders. So far, simple retroviral …

The broad application of retroviral vectors for gene delivery is still hampered by the difficulty
to reproducibly establish high vector producer cell lines generating sufficient amounts of …

Improved, human‐based packaging cell lines allow the production of high‐titer, RCR‐free
retroviral vectors. The utility of these cell lines for the production of clinical grade vectors …

Retroviruses are currently the most widely used vectors in clinical trials for gene therapy.
These vectors are, however, limited by low titres partly due to the restrictive nature of …